Ambrisentan | CAS No. 177036-94-1

Ambrisentan

Basic Information

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CAS Number

177036-94-1

Molecular Formula

C22H22N2O4

Molecular Weight

378.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Powder

Melting Point

184-191°C

Boiling Point

551.1°C at 760 mmHg

Flash Point

287.1±32.9 °C

SMILES

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CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C

InChI

InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

InChIKey

OUJTZYPIHDYQMC-LJQANCHMSA-N

LogP

3.515640000000002

Topological Polar Surface Area

81.54 Å²

Hydrogen Bond Donor/Acceptor

1 / 6

Complexity

475

Safety Information

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Hazard Statement

H303 May be harmful if swallowed
Acute toxicity, oral

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Synonyms & References

English

AMBRISENTAN [WHO-DD]
(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid
Benzenepropanoic acid, alpha-[(4,6-dimethyl-2-pyrimidinyl)oxy]-beta-methoxy-beta-phenyl-, (alphaS)-
Volibris (TN)
GSK1325760A
AMBRISENTAN [VANDF]
AC-9015
AB01566890_01
Volibris
(2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid
GSK-1325760
(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid
(S)-2-(4,6-Dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid
ambrisentanum
LU-208075
HW6NV07QEC
Tox21_111967_1
DE-0223
(S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid
SCHEMBL3679
AKOS015994540
177036-94-1
CCG-268386
Pulmonext
EX-A3315
EN300-7368573
DTXCID2026282
FD7219
(2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
Ambrisentan [INN:BAN:JAN]
(s)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid

MDL Number

MFCD09842330

Customs Code

2933599090

FAQ

What is Ambrisentan (CAS: 177036-94-1)?

Ambrisentan (CAS: 177036-94-1) is a selective endothelin receptor antagonist used primarily in the treatment of pulmonary arterial hypertension. It works by blocking the action of endothelin, a substance that causes blood vessels to narrow. The chemical formula of Ambrisentan is C15H17N5O2S, and it is a white to off-white solid at room temperature with good solubility in certain organic solvents.

What are the main uses of Ambrisentan (CAS: 177036-94-1)?

Ambrisentan (CAS: 177036-94-1) is mainly used as a medication for pulmonary arterial hypertension. It helps to relax and widen blood vessels, improving blood flow and reducing pressure in the lungs. Additionally, it is used in research for studying endothelin pathway inhibition and may have potential applications in other cardiovascular conditions.

Is Ambrisentan (CAS: 177036-94-1) safe?

Ambrisentan (CAS: 177036-94-1) is generally considered safe when used as directed under medical supervision. However, like all medications, it may cause side effects such as dizziness, headache, and swelling. Proper handling and storage are important to maintain its efficacy and safety. Always follow guidelines provided by healthcare professionals and regulatory bodies.

How should Ambrisentan (CAS: 177036-94-1) be stored?

Ambrisentan (CAS: 177036-94-1) should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 25°C (59°F to 77°F) and should be protected from moisture. Store in a tightly sealed container to prevent degradation and contamination.