Valganciclovir hydrochloride

Basic Information

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CAS Number

175865-59-5

Molecular Formula

C14H23ClN6O5

Molecular Weight

390.83 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

161-172°C

Boiling Point

629.1°C at 760 mmHg

Solubility

H2O: ≥8mg/mL

SMILES

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CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1N=C(NC2=O)N)N.Cl

InChI

InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1

InChIKey

ZORWARFPXPVJLW-MTFPJWTKSA-N

LogP

-1.0148999999999992

Topological Polar Surface Area

171.36999999999998 Å²

Hydrogen Bond Donor/Acceptor

6 / 11

Complexity

528

Safety Information

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Hazard Statement

H340 May cause genetic defects
Germ cell mutagenicity

H351 Suspected of causing cancer
Carcinogenicity

H360 May damage fertility or the unborn child
Reproductive toxicity

Synonyms & References

English

HY-A0032A
NCGC00168779-01
L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl ester, monohydrochloride
MFCD08460118
UNII-4P3T9QF9NZ
V0158
VALGANCICLOVIR HYDROCHLORIDE (MART.)
Ro-10-79070/194
(2RS)-2-((2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl (2S)-2-amino-3-methylbutanoate monohydrochloride
Valganciclovir hydrochloride (JAN/USP)
ZORWARFPXPVJLW-MTFPJWTKSA-N
NSC760349
AKOS015963325
L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester, monohydrochloride hydrate
DTXSID9046784
CHEMBL1200454
Valganciclovir HCl
VALGANCICLOVIR (AS HYDROCHLORIDE)
AC-7501
Valganciclovirhydrochloride
R-127
Valixa
Valganciclovir hydrochloride (USAN:USP)
SMR002533167
BS-1015
Tox21_112640
CCG-213225
NSC 760349
RS-79070-194
L-Valine, ester with 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine, monohydrochloride
VALGANCICLOVIR HYDROCHLORIDE (USP-RS)

MDL Number

MFCD08460118

FAQ

What is Valganciclovir hydrochloride (CAS: 175865-59-5)?

Valganciclovir hydrochloride (CAS: 175865-59-5) is a prodrug of ganciclovir, used primarily in the treatment of viral infections. It has the chemical formula C14H18N6O7·HCl and is known for its antiviral properties, particularly against cytomegalovirus (CMV). It is a white to off-white crystalline powder, soluble in water, and commonly used in pharmaceutical formulations.

What are the main uses of Valganciclovir hydrochloride (CAS: 175865-59-5)?

Valganciclovir hydrochloride (CAS: 175865-59-5) is mainly used in the pharmaceutical industry for treating cytomegalovirus (CMV) retinitis and other CMV-related infections, especially in immunocompromised patients. It is also used in research for studying antiviral mechanisms and in the development of related therapeutic agents.

Is Valganciclovir hydrochloride (CAS: 175865-59-5) safe?

Valganciclovir hydrochloride (CAS: 175865-59-5) is generally considered safe when used as directed in medical treatment. However, it should be handled with care, and protective measures such as gloves and goggles are recommended during preparation and administration. Safety standards are in place to ensure proper use and minimize risks.

How should Valganciclovir hydrochloride (CAS: 175865-59-5) be stored?

Valganciclovir hydrochloride (CAS: 175865-59-5) should be stored in a cool, dry place away from light. It is typically kept in airtight containers at a temperature between 15°C to 25°C. Proper storage ensures stability and prolongs shelf life, preventing degradation or contamination.