N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine

Basic Information

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CAS Number

175453-07-3

Molecular Formula

C23H20N2O4

Molecular Weight

388.42 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

155.3 ºC

Boiling Point

514.13°C (rough estimate)

Refractive Index

1.6300 (estimate)

SMILES

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C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CN=CC=C4)C(=O)O

InChI

InChI=1S/C23H20N2O4/c26-22(27)21(12-15-6-5-11-24-13-15)25-23(28)29-14-20-18-9-3-1-7-16(18)17-8-2-4-10-19(17)20/h1-11,13,20-21H,12,14H2,(H,25,28)(H,26,27)/t21-/m0/s1

InChIKey

JQLPMTXRCLXOJO-NRFANRHFSA-N

LogP

3.6160000000000023

Topological Polar Surface Area

88.52 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

561

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

3-Pyridin-3-yl-L-alanine, N-FMOC protected
CS-W011736
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid
Fmoc-L-(3-pyridyl)alanine
Fmoc--(3-pyridyl)-Ala-OH
AS-14757
MFCD00144887
AM83728
Fmoc-D-3-(3-pyridyl)-alanine
FMOC-ALA(3-PYRI)-OH
Fmoc-beta-(3-pyridyl)-Ala-OH, >=98.0%
(S)-N-Fmoc-(3-Pyridyl)alanine
EN300-317003
Fmoc-beta-(3-pyridyl)-Ala-OH
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(pyridin-3-yl)propanoic acid
AKOS015908038
(S)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-3-(PYRIDIN-3-YL)PROPANOIC ACID
A50241
FMOC-3'-PYRIDYL-L-ALA
Fmoc-3-(3-pyridyl)-L-alanine
AC-9959
SCHEMBL119546
HY-W011020
3-Pyridinepropanoic acid, alpha-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (alphaS)-
J-011114
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-pyridin-3-ylpropanoic acid
N-Fluorenemethoxycarbonyl-L-3-(3-Pyridyl) Alanine
FMOC-3-PAL-OH
175453-07-3
N-FMOC-3-(3-PYRIDYL)-L-ALANINE
Fmoc- beta -(3-pyridyl)-Ala-OH

MDL Number

MFCD00144887

FAQ

What are the physical and chemical properties of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine (CAS: 175453-07-3)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine (CAS: 175453-07-3) is a crystalline compound with a molecular weight of approximately 463.43 g/mol. It has low solubility in water but is soluble in organic solvents like methanol and acetonitrile. This compound is stable under normal conditions but reacts with strong bases and acids. It is often used in medicinal chemistry for the synthesis of bioactive compounds.

How is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine (CAS: 175453-07-3) typically synthesized?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine is synthesized through multi-step processes involving coupling reactions, protecting group strategies, and deprotection steps. Common methods include the use of fluorenylmethoxycarbonyl (Fmoc) protecting group and various coupling reagents such as HATU or EDC/NHS. The final product is obtained with good yield and high purity via purification techniques like flash chromatography.

What industries use N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine (CAS: 175453-07-3)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine (CAS: 175453-07-3) is primarily used in the pharmaceutical industry for the development of new drug candidates. It also finds applications in polymer chemistry, where it can serve as a building block for synthetic polymers. Additionally, it is used in the production of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine (CAS: 175453-07-3)?

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-L-alanine (CAS: 175453-07-3), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid exposure to the compound. Spills should be cleaned up immediately using appropriate methods, and the material safety data sheet (MSDS) should be consulted for detailed safety information.