5-Methoxy-1H-pyrrolo[3,2-b]pyridine

Basic Information

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CAS Number

17288-40-3

Molecular Formula

C8H8N2O

Molecular Weight

148.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

108-112 °C

Boiling Point

285 ºC

Flash Point

98 ºC

Refractive Index

1.647

SMILES

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COC1=NC2=C(C=C1)NC=C2

InChI

InChI=1S/C8H8N2O/c1-11-8-3-2-6-7(10-8)4-5-9-6/h2-5,9H,1H3

InChIKey

WTIFEVSWZUSXQL-UHFFFAOYSA-N

LogP

1.5715

Topological Polar Surface Area

37.91 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

140

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

DTXSID90415902
17288-40-3
MFCD08688601
5-methoxypyrrolo[3,2-b]pyridine
AM20070199
AKOS006282107
5-methoxy-1H-pyrrolo[3,2-b]-pyridine
5-methoxy-pyrrolo[3,2-b]pyridine
DS-0985
5-Methoxy-4-azaindole
5-Methoxy-4-Aza-1H-Indole
SCHEMBL1150368
A811459
5-methoxy-1H-pyrrolo[3,2-b]pyridine
1H-pyrrolo[3,2-b]pyridine, 5-methoxy-
EN300-312556
5-methoxypyrrolo-[3,2-b]pyridine
5-Methoxy-4-azaindole, 95%
FT-0659551
InChI=1/C8H8N2O/c1-11-8-3-2-6-7(10-8)4-5-9-6/h2-5,9H,1H
PB34310
WTIFEVSWZUSXQL-UHFFFAOYSA-N
CS-W008514
YXU
5-Methoxy-1H-pyrrolo[3,2-b]pyridine
1,3-Dihydro-2H-pyrrolo[3,2-b]pyridin-2-one
1H-Pyrrolo[3,2-b]pyridine,5-methoxy-
5-Methoxy-4-azaindole,5-methoxy-1H-pyrrolo[3,2-b]pyridine
5-Methoxypyrrolo[3,2-b]pyridine
5-Metho×y-4-azaindole,5-Metho×y-1H-pyrrolo[3,2-b]pyridine
KSC534G9L

MDL Number

MFCD08688601

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 5-Methoxy-1H-pyrrolo[3,2-b]pyridine (CAS: 17288-40-3)?

5-Methoxy-1H-pyrrolo[3,2-b]pyridine is a crystalline solid with a molecular weight of approximately 184.21 g/mol. It has a solubility of around 1.5 g/100 mL in water and is sparingly soluble in common organic solvents like methanol and acetonitrile. The compound is stable under normal conditions but can react with strong acids or bases to form other derivatives. It shows weak basicity in aqueous solutions.

How is 5-Methoxy-1H-pyrrolo[3,2-b]pyridine (CAS: 17288-40-3) typically synthesized?

5-Methoxy-1H-pyrrolo[3,2-b]pyridine is typically synthesized via the methylation of 1H-pyrrolo[3,2-b]pyridine followed by a condensation reaction. This process involves the use of a base like sodium methoxide and a condensing agent such as N,N'-carbonyldiimidazole (CDI) to form the desired methoxy derivative with good yield and selectivity.

What industries use 5-Methoxy-1H-pyrrolo[3,2-b]pyridine (CAS: 17288-40-3)?

5-Methoxy-1H-pyrrolo[3,2-b]pyridine is used in various industries. In the pharmaceutical industry, it serves as a building block for drug synthesis. It is also utilized in the polymer industry for developing functional polymers with specific properties. Additionally, it finds use in sensor technology and semiconductor applications due to its electronic properties.

What precautions should be taken when handling 5-Methoxy-1H-pyrrolo[3,2-b]pyridine (CAS: 17288-40-3)?

When handling 5-Methoxy-1H-pyrrolo[3,2-b]pyridine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a fume hood to minimize exposure. Spills should be cleaned up promptly using appropriate absorbent materials. For detailed safety information, refer to the Safety Data Sheet (SDS).