5-Methoxy-1H-pyrrolo[3,2-b]pyridine(CAS: 17288-40-3)

5-Methoxy-1H-pyrrolo[3,2-b]pyridine is a crystalline solid with a molecular weight of approximately 184.21 g/mol. It has a solubility of around 1.5 g/100 mL in water and is sparingly soluble in common organic solvents like methanol and acetonitrile. The compound is stable under normal conditions but can react with strong acids or bases to form other derivatives. It shows weak basicity in aqueous solutions.

5-Methoxy-1H-pyrrolo[3,2-b]pyridine is typically synthesized via the methylation of 1H-pyrrolo[3,2-b]pyridine followed by a condensation reaction. This process involves the use of a base like sodium methoxide and a condensing agent such as N,N'-carbonyldiimidazole (CDI) to form the desired methoxy derivative with good yield and selectivity.

5-Methoxy-1H-pyrrolo[3,2-b]pyridine is used in various industries. In the pharmaceutical industry, it serves as a building block for drug synthesis. It is also utilized in the polymer industry for developing functional polymers with specific properties. Additionally, it finds use in sensor technology and semiconductor applications due to its electronic properties.

When handling 5-Methoxy-1H-pyrrolo[3,2-b]pyridine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a fume hood to minimize exposure. Spills should be cleaned up promptly using appropriate absorbent materials. For detailed safety information, refer to the Safety Data Sheet (SDS).