2-chloro-3-fluoropyridine

Basic Information

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CAS Number

17282-04-1

Molecular Formula

C5H3ClFN

Molecular Weight

131.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

80°C/80mmHg

Refractive Index

n20/D 1.509(lit.)

SMILES

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C1=CC(=C(N=C1)Cl)F

InChI

InChI=1S/C5H3ClFN/c6-5-4(7)2-1-3-8-5/h1-3H

InChIKey

SVAZIMBLBHOVIR-UHFFFAOYSA-N

LogP

1.8741

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

78.8

Safety Information

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GHS Hazard Pictograms

H302

H318

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class Comb liq Class Comb liq

Synonyms & References

English

SVAZIMBLBHOVIR-UHFFFAOYSA-N
AC-2663
FT-0658919
fluorochloropyridine
DTXSID60382298
Z850328566
MFCD03095302
PS-9140
F0001-0627
EN300-56059
AKOS005063977
2-Chloro-3-fluoropyridine
RB1059
2-Chloro-3-fluoropyridine, 97%
C2447
SCHEMBL105057
17282-04-1
W-206038
Pyridine, 2-chloro-3-fluoro-
AB13662
FT-0637521
CS-W020185
AM20050878
2-Chloro-3-Fluoro Pyridine
BCP22126
3-FLUORO-2-CHLOROPYRIDINE
2-chloro-3-fluoro picoline
2-Chlor-3-fluorpyridin
2-Chloro-3-fluoropyridin
2-Chloro-3-fluoro-pyridine
chlorofluoropyridine

MDL Number

MFCD03095302

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-chloro-3-fluoropyridine (CAS: 17282-04-1)?

2-Chloro-3-fluoropyridine (CAS: 17282-04-1) is a crystalline compound with a molecular weight of approximately 147.58 g/mol. It has a melting point around 74-77°C and is poorly soluble in water. The compound exhibits limited reactivity, primarily through substitution reactions at the chlorine and fluorine atoms.

How is 2-chloro-3-fluoropyridine (CAS: 17282-04-1) typically synthesized?

2-Chloro-3-fluoropyridine is typically synthesized by halogenation of pyridine derivatives. A common method involves the reaction of 3-fluoropyridine with chlorine gas in the presence of a Lewis acid catalyst like aluminum chloride. The yield and selectivity are generally good.

What industries use 2-chloro-3-fluoropyridine (CAS: 17282-04-1)?

2-Chloro-3-fluoropyridine is primarily used in pharmaceuticals for the synthesis of various drug intermediates. It also finds applications in the development of novel materials, specifically in polymers and sensors due to its unique electronic properties.

What precautions should be taken when handling 2-chloro-3-fluoropyridine (CAS: 17282-04-1)?

When handling 2-chloro-3-fluoropyridine, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed handling and disposal procedures.