2-chloro-3-fluoropyridine(CAS: 17282-04-1)

2-Chloro-3-fluoropyridine (CAS: 17282-04-1) is a crystalline compound with a molecular weight of approximately 147.58 g/mol. It has a melting point around 74-77°C and is poorly soluble in water. The compound exhibits limited reactivity, primarily through substitution reactions at the chlorine and fluorine atoms.

2-Chloro-3-fluoropyridine is typically synthesized by halogenation of pyridine derivatives. A common method involves the reaction of 3-fluoropyridine with chlorine gas in the presence of a Lewis acid catalyst like aluminum chloride. The yield and selectivity are generally good.

2-Chloro-3-fluoropyridine is primarily used in pharmaceuticals for the synthesis of various drug intermediates. It also finds applications in the development of novel materials, specifically in polymers and sensors due to its unique electronic properties.

When handling 2-chloro-3-fluoropyridine, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed handling and disposal procedures.