Ezatiostat | CAS No. 168682-53-9

Ezatiostat

Basic Information

View in Editor

CAS Number

168682-53-9

Molecular Formula

C27H35N3O6S

Molecular Weight

529.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

View in Editor

CCOC(=O)C(CCC(=O)NC(CSCC1=CC=CC=C1)C(=O)NC(C2=CC=CC=C2)C(=O)OCC)N

InChI

InChI=1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1

InChIKey

GWEJFLVSOGNLSS-WPFOTENUSA-N

LogP

2.4957999999999996

Topological Polar Surface Area

136.82 Å²

Hydrogen Bond Donor/Acceptor

4 / 9

Complexity

725

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MFCD27982957
HY-13634A
Ezatiostat [INN]
Glycine, N-(N-L-gamma-glutamyl-S-(phenylmethyl)-L-cysteinyl)-D-2-phenyl-, diethyl ester
NS00072776
168682-53-9
057D10I8S8
1-(5-Chloro-2-{2-[(2R)-4-(4-fluorobenzyl)-2-methyl-1-piperazinyl]-2-oxoethoxy}phenyl)urea
DTXSID40168592
Ezatiostat(TER199; TLK199)
NSC-758484
DB05460
Glycine, L-g-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
NCGC00263221-01
TLK199
Terrapin 199
CS-1713
TLK-199
AKOS005266721
AS-74082
gamma-Glutamyl-S-(benzyl)-cysteinyl-R(-)-phenylglycine diethyl ester
ethyl (2S)-2-amino-4-{[(1R)-2-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]carbamoyl}ethyl]carbamoyl}butanoate
CHEMBL2110585
J-690234
ETHYL (2R)-((4S)-4-AMINO-5-ETHOXY-5-OXOPENTANOYL)-S-BENZYL-L-CYSTEINYL-2-PHENYLGLYCINATE
TER 199
UNII-057D10I8S8
Q27095680
EX-A345
GLYCINE, L-.GAMMA.-GLUTAMYL-S-(PHENYLMETHYL)-L-CYSTEINYL-2-PHENYL-, DIETHYL ESTER, (2R)-
Glycine, L-gamma-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, diethyl ester, (2R)-

MDL Number

MFCD27982957

FAQ

What is Ezatiostat (CAS: 168682-53-9)?

Ezatiostat is a potent, selective inhibitor of STAT3 signaling, used in the treatment of hematologic malignancies. It has a molecular formula of C26H24N6O2 and is a white to off-white solid.

What are the main uses of Ezatiostat (CAS: 168682-53-9)?

Ezatiostat is primarily used in clinical trials for the treatment of hematologic malignancies, such as acute myeloid leukemia and multiple myeloma. It is a promising therapeutic agent for targeted cancer therapy.

Is Ezatiostat (CAS: 168682-53-9) safe?

Ezatiostat is generally considered safe when used under medical supervision. However, like many drugs, it may cause side effects such as nausea, fatigue, and liver enzyme abnormalities. Proper handling and adherence to medical guidelines are essential.

How should Ezatiostat (CAS: 168682-53-9) be stored?

Ezatiostat should be stored in a cool, dry place away from direct sunlight and moisture. It should be kept in a tightly closed container to protect it from light and air. The recommended storage temperature is between 15-30°C (59-86°F).