1-(2-{4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one | CAS No. 167933-07-5

1-(2-{4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one

Basic Information

CAS Number

167933-07-5

Molecular Formula

C20H21F3N4O

Molecular Weight

390.41 g/mol

AD

Basic Physical Properties

Solubility

DMSO: soluble10mg/mL, clear

C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F

InChI

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

InChIKey

PPRRDFIXUUSXRA-UHFFFAOYSA-N

LogP

3.170600000000001

Topological Polar Surface Area

44.269999999999996 Ų

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

550

Safety Information

View Safety Information

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral
H315 Causes skin irritation
Skin corrosion/irritation
H319 Causes serious eye irritation
Serious eye damage/eye irritation
H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

  • BIMT 17 BS
  • NCGC00386567-02
  • FLIBANSERIN [WHO-DD]
  • A810922
  • DTXCID8090936
  • HMS3885K21
  • 1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1,3-dihydro-2H-benzimidazol-2-one
  • CS-4671
  • Flibanserin [USAN]
  • L001463
  • NCGC00386567-01
  • NCGC00386567-03
  • MFCD00918402
  • FT-0659246
  • flibanserinum
  • 1-(2-(4-(alpha,alpha,alpha-Trifluoro-m-tolyl)-1-piperazinyl)ethyl)-2-benzimidazolinone
  • DB04908
  • Addyi
  • Flibanserin [USAN:INN]
  • Girosa (proposed trade name)
  • 1-(2-(4-alpha,alpha,alpha-Trifluoro-m-tolyl)-1-piperazinyl)ethyl)-2-benzimidazolinone
  • 2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-
  • UNII-37JK4STR6Z
  • HY-A0095
  • HSDB 8278
  • 1-(2-(4-alpha,alpha,alpha-Trifluoro-m-tolyl)-1-(piperazinyl)ethyl)-2-benzimidazolinone
  • 1-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one
  • Female Viagra
  • Flibanserin
  • Q415996
  • FLIBANSERIN [MART.]

MDL Number

MFCD00918402

FAQ

What is 1-(2-{4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 167933-07-5)?

1-(2-{4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 167933-07-5) is a synthetic organic compound with a complex structure containing a benzimidazole ring and a piperazine group. It is known for its pharmaceutical applications and is often used as an intermediate in drug development. The compound is typically a white to off-white solid with good solubility in polar solvents.

What are the main uses of 1-(2-{4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 167933-07-5)?

This compound is primarily used in pharmaceutical research as a key intermediate for the synthesis of various drugs, particularly those targeting neurological and psychiatric conditions. It may also find applications in chemical synthesis, drug delivery systems, and as a building block for more complex molecules. Its unique structure makes it valuable for developing compounds with specific biological activities.

Is 1-(2-{4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 167933-07-5) safe?

The safety of 1-(2-{4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 167933-07-5) depends on its application and handling. It is generally considered safe when used in controlled laboratory settings and following proper safety protocols. However, as with many chemical compounds, it should be handled with care, using appropriate personal protective equipment (PPE) to minimize exposure risks.

How should 1-(2-{4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one (CAS: 167933-07-5) be stored?

To ensure stability and safety, this compound should be stored in a cool, dry, and well-ventilated area, away from light. It is recommended to keep it in a sealed container made of glass or high-density polyethylene (HDPE) to prevent moisture ingress. Storage at temperatures below 25°C and in low humidity conditions is optimal for maintaining its chemical integrity.

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