Naltrexone HCl

Basic Information

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CAS Number

16676-29-2

Molecular Formula

C20H24ClNO4

Molecular Weight

377.87 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

274-2760C

Boiling Point

558.1°C at 760 mmHg

Water Solubility

Soluble in water at 50mg/ml.

Solubility

H2O: 50 mg/mL, clear, colorless

SMILES

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Cl.Oc1ccc2C[C@H]3N(CC4CC4)CC[C@]5([C@H]6Oc1c25)[C@@]3(O)CCC6=O

InChI

InChI=1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1

InChIKey

RHBRMCOKKKZVRY-ITLPAZOVSA-N

LogP

1.9471999999999994

Topological Polar Surface Area

70.0 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

621

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Sensitiveness

Light Sensitive

Synonyms & References

English

Naltrexone hydrochloride
17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onehydroch
17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydr
17-(cyclopropylmethyl)-4,5-alpha-oxy-3,14-dihydoxy-morphinan-6-onhydrochlo
17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-morphinan-6-onhydrochlor
en1639a
n-cyclopropylmethyl-noroxymorphonehydrochloride
nih8503
N-CYCLOPROPYLMETHYL-14-HYDROXYDI-HYDROMORPHINONE HYDROCHLORIDE
Naltrexone HCl
Naltrexone (Hydrochloride)
Naltrexone Hydrochlo
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one hydrochloride
Nalmefene Impurity C
(5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
ReVia
Depade
Nalorex
Antaxone
Ccris 1168
(5-alpha)-id
Einecs 240-723-0
HIC-A90670115
Trexan
En 1639A
NIH 8503
Nemexin
N-Cyclopropylmethyl-noroxymorphone hydrochloride
MLS000069607
Naltrexone hydrochloride [USP]
Z6375YW9SF

MDL Number

MFCD00069324

FAQ

What are the physical and chemical properties of Naltrexone HCl (CAS: 16676-29-2)?

Naltrexone HCl (CAS: 16676-29-2) is a white or practically white crystalline powder. It has a molecular weight of 374.82 g/mol. Naltrexone HCl is slightly soluble in water and ethanol. It is stable under normal conditions but reacts with strong acids. It is not flammable and has low reactivity with common chemicals.

How is Naltrexone HCl (CAS: 16676-29-2) typically synthesized?

Naltrexone HCl is typically synthesized via a multi-step process involving the conversion of naltrexone to its hydrochloride salt. Common methods include the reaction of naltrexone with hydrochloric acid under controlled conditions. This synthesis is highly selective and yields up to 95% of the product. The process requires careful control of pH and temperature to ensure high purity and yield.

What industries use Naltrexone HCl (CAS: 16676-29-2)?

Naltrexone HCl (CAS: 16676-29-2) is primarily used in the pharmaceutical industry for the treatment of opioid dependence. It is also utilized in research and development for its analgesic and anti-addictive properties. This compound is not commonly used in other industries such as polymers, sensors, or semiconductors.

What precautions should be taken when handling Naltrexone HCl (CAS: 16676-29-2)?

When handling Naltrexone HCl (CAS: 16676-29-2), it is important to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of spill, use caution and follow proper spill handling procedures as outlined in the Safety Data Sheet (SDS). Handle in a well-ventilated area or fume hood to avoid inhalation of the compound.