Afatinib Impurity 64

Basic Information

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CAS Number

16499-57-3

Molecular Formula

C8H5FN2O

Molecular Weight

164.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

246.0 to 250.0 deg-C

Boiling Point

293.3°C at 760 mmHg

Density

1.44

Flash Point

131.2 oC

Refractive Index

1.642

SMILES

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C1=CC2=C(C=C1F)N=CNC2=O

InChI

InChI=1S/C8H5FN2O/c9-5-1-2-6-7(3-5)10-4-11-8(6)12/h1-4H,(H,10,11,12)

InChIKey

KCORZHJVTZIZFD-UHFFFAOYSA-N

LogP

1.4745

Topological Polar Surface Area

46.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

229

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SCHEMBL24819
FT-0682244
CHEMBL1949849
BB 0305912
7-fluoro-1H-quinazolin-4-one
7-fluoro-4-quinazolinone
7-Fluoro-4-quinazolinol
W-205942
7-fluoroquinazoline-4(3H)-one
A3665
F2167-7140
7-Fluoroquinazolin-4-ol
SY034747
EN300-15355
Z133595436
7-fluoro-4-hydroxyquinazoline
PB18807
7-Fluoro-quinazolin-4-ol
AB1098
DTXSID60426989
7-FLURO-3H-QUINAZOLIN-4-ONE
MFCD05664874
AKOS015917999
HMS1734C04
F15666
7-Fluoroquinazolin-4(1H)-one
7-FLUORO-3H-QUINAZOLIN-4-ONE
AC-8530
FS-2639
7-Fluoro-3,4-dihydroquinazolin4-one
7-Fluoroquinazolin-4-(3H)-one

MDL Number

MFCD07689443

Customs Code

2933990090

FAQ

What is Afatinib Impurity 64 (CAS: 16499-57-3)?

Afatinib Impurity 64 (CAS: 16499-57-3) is a byproduct of the synthesis of afatinib, a tyrosine kinase inhibitor used in the treatment of non-small cell lung cancer. It consists of a complex mixture of compounds, including afatinib and other related impurities.

What are the main uses of Afatinib Impurity 64 (CAS: 16499-57-3)?

Afatinib Impurity 64 (CAS: 16499-57-3) is primarily used as a quality control reference material in the pharmaceutical industry to ensure the purity and consistency of afatinib products. It is also used in analytical chemistry for impurity profiling and identification.

Is Afatinib Impurity 64 (CAS: 16499-57-3) safe?

Afatinib Impurity 64 (CAS: 16499-57-3) is generally considered safe when handled properly. However, it is important to follow safety guidelines, such as wearing appropriate personal protective equipment (PPE) and ensuring proper ventilation during handling. Direct contact with skin or ingestion should be avoided.

How should Afatinib Impurity 64 (CAS: 16499-57-3) be stored?

Afatinib Impurity 64 (CAS: 16499-57-3) should be stored in a tightly sealed container at room temperature (15-30°C) away from direct sunlight and moisture. It is crucial to maintain a dry environment to prevent degradation. Avoid exposure to high temperatures and maintain good air circulation to ensure the stability of the compound.