2-Iodo-5-methylthiophene

Basic Information

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CAS Number

16494-36-3

Molecular Formula

C5H5IS

Molecular Weight

224.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

81-83 °C/10 mmHg

Refractive Index

n20/D 1.626(lit.)

SMILES

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CC1=CC=C(S1)I

InChI

InChI=1S/C5H5IS/c1-4-2-3-5(6)7-4/h2-3H,1H3

InChIKey

NAZNQEXKAPLVKC-UHFFFAOYSA-N

LogP

2.6611200000000013

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

65.1

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

J-509717
MFCD00022492
C5H5IS
2-Iodo-5-methylthiophene
CS-W014227
SCHEMBL80621
DS-15211
DTXSID60167825
Thiophene, 2-iodo-5-methyl-
A3661
2-Iodo-5-methylthiophene, 97%
EN300-646056
AMY31922
AKOS015854007
16494-36-3
BIDD:GT0402
FT-0637370
SY016776
2-iodo-5-methyl-thiophene
2-IODO-5-METHYLTHIOP
2-Methyl-5-iodothiophene
2-Iodo-5-methylthiophene 97%

MDL Number

MFCD00022492

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-Iodo-5-methylthiophene (CAS: 16494-36-3)?

2-Iodo-5-methylthiophene (CAS: 16494-36-3) is a crystalline solid with a molecular weight of approximately 230.06 g/mol. It has a low solubility in water but dissolves readily in organic solvents like dichloromethane and acetone. Chemically, it is highly reactive towards nucleophiles, making it a valuable precursor in various organic synthesis reactions.

How is 2-Iodo-5-methylthiophene (CAS: 16494-36-3) typically synthesized?

2-Iodo-5-methylthiophene (CAS: 16494-36-3) can be synthesized via the reaction of thiophene with iodine in the presence of a Lewis acid catalyst, such as aluminum chloride. The process involves mild heating and is known for its good yield and selectivity.

What industries use 2-Iodo-5-methylthiophene (CAS: 16494-36-3)?

2-Iodo-5-methylthiophene (CAS: 16494-36-3) is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various drugs and also finds applications in the preparation of functional polymers for electronic devices and sensors.

What precautions should be taken when handling 2-Iodo-5-methylthiophene (CAS: 16494-36-3)?

When handling 2-Iodo-5-methylthiophene (CAS: 16494-36-3), safety measures include using personal protective equipment (PPE) such as gloves and goggles. Work should be conducted in a well-ventilated area or a fume hood. In case of a spill, immediately neutralize with sodium bisulfite and dispose of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.