Efinaconazole | CAS No. 164650-44-6

Efinaconazole

Basic Information

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CAS Number

164650-44-6

Molecular Formula

C18H22F2N4O

Molecular Weight

348.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Vapor Pressure

1.57X10-9 mm Hg at 25 °C (est)

SMILES

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CC(C(CN1C=NC=N1)(C2=C(C=C(C=C2)F)F)O)N3CCC(=C)CC3

InChI

InChI=1S/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/m1/s1

InChIKey

NFEZZTICAUWDHU-RDTXWAMCSA-N

LogP

2.4846000000000004

Topological Polar Surface Area

54.18 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

470

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

KP-103
Efinaconazole [INN]
UNII-J82SB7FXWB
SureCN300738
AC1LAJ21
Efinaconazole [USAN:INN]
CHEMBL2103877
(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
KP 103
USAN
(αR,βR)-, α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
(alphaR,betaR)-alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
KP 103 (pharmaceutical)
Jublia
Efinaconazole
Efinaconazole(KP 103)
(R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
(2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
J82SB7FXWB
KP103
efinaconazolum
efinaconazol
Clenafin (TN)
AK315814
Jublia (TN)
Efinaconazole (JAN/USAN/INN)
C18
1-Piperidineethanol, alpha-(2,4-difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-ylmethyl)-, (alphaR,betaR)-
Ju
(2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

MDL Number

MFCD00936406

FAQ

What is Efinaconazole (CAS: 164650-44-6)?

Efinaconazole is an antifungal medication with the chemical formula C21H23ClN4O2. It belongs to the allylamine class of antifungal agents and is known for its broad-spectrum activity against dermatophytes, yeasts, and molds. It is commonly used in topical formulations for treating fungal infections of the skin and nails.

What are the main uses of Efinaconazole (CAS: 164650-44-6)?

Efinaconazole is primarily used in dermatology to treat fungal infections such as athlete's foot, ringworm, and jock itch. It is also used for onychomycosis (fungal nail infections) and is found in various over-the-counter and prescription topical creams. Additionally, it may have applications in research and industrial settings related to antifungal development.

Is Efinaconazole (CAS: 164650-44-6) safe?

Efinaconazole is generally considered safe when used as directed, but it may cause skin irritation or allergic reactions in some individuals. It should be handled with care, following standard safety protocols for chemical exposure. Always consult a healthcare professional before use and follow safety guidelines to minimize risks.

How should Efinaconazole (CAS: 164650-44-6) be stored?

Efinaconazole should be stored in a cool, dry place away from direct sunlight. It is typically kept in a sealed container at a temperature between 15°C to 25°C. Proper storage ensures stability and effectiveness, and it should be protected from moisture and high humidity conditions.