N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine | CAS No. 1634-89-5

N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine

Basic Information

CAS Number

1634-89-5

Molecular Formula

C15H18N2O7

Molecular Weight

338.32 g/mol

AD

Basic Physical Properties

C1=CC=C(C=C1)COC(=O)NC(CCC(=O)O)C(=O)NCC(=O)O

InChI

InChI=1S/C15H18N2O7/c18-12(19)7-6-11(14(22)16-8-13(20)21)17-15(23)24-9-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,16,22)(H,17,23)(H,18,19)(H,20,21)/t11-/m0/s1

InChIKey

FDTUHSFTKCRNSD-NSHDSACASA-N

LogP

0.3470000000000006

Topological Polar Surface Area

142.02999999999997 Ų

Hydrogen Bond Donor/Acceptor

4 / 9

Complexity

461

Synonyms & References

English

  • (S)-4-(((Benzyloxy)carbonyl)amino)-5-((carboxymethyl)amino)-5-oxopentanoicacid
  • MFCD00191093
  • 1634-89-5
  • CS-0675663
  • (S)-4-(benzyloxycarbonylamino)-5-(carboxymethylamino)-5-oxopentanoic acid
  • (4S)-5-(carboxymethylamino)-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
  • HY-P5012
  • carbobenzoxy-l-glutamyl glycine
  • (S)-4-(((Benzyloxy)carbonyl)amino)-5-((carboxymethyl)amino)-5-oxopentanoic acid
  • SCHEMBL1122463
  • Z-Glu-Gly-OH
  • Cbz-Glu-Gly-OH
  • 5-(carboxymethylamino)-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
  • Glycine,N-[(phenylmethoxy)carbonyl]-L-a-glutamyl- (9CI)
  • Z-GLU-GLY-OH
  • carbobenzoxy-L-glutamylglycine
  • Z-Glu-Gly-OH99%
  • Z-L-A-GLUTAMYL-L-GLYCINE
  • Z-L-ALPHA-GLUTAMYL-L-GLYCINE
  • 4-(benzyloxycarbonylamino)-5-(carboxymethylamino)-5-keto-valeric acid

MDL Number

MFCD00191093

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS: 1634-89-5)?

N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS 1634-89-5) is a crystalline compound with a molecular weight of approximately 322.29 g/mol. It has a solubility of about 0.02 g/100 mL in water. Chemically, it is a reactive compound, and its reactivity is influenced by its ester and amide functional groups. It is prone to hydrolysis under acidic conditions.

How is N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS: 1634-89-5) typically synthesized?

N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS 1634-89-5) is typically synthesized via a multi-step reaction involving coupling of benzyloxycarbonyl chloride with L-glutamic acid. The reaction is catalyzed by an appropriate coupling agent such as HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) and a base like diisopropylethylamine. The yield is generally around 70-80%, with good regioselectivity.

What industries use N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS: 1634-89-5)?

N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS 1634-89-5) is mainly used in the pharmaceutical industry. It serves as a precursor in the synthesis of various bioactive molecules and peptides. Additionally, it can be used in research and development for drug discovery and as a building block in chemical synthesis.

What precautions should be taken when handling N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS: 1634-89-5)?

When handling N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS 1634-89-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be carefully cleaned up using appropriate spill kits. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.

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