N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine(CAS: 1634-89-5)

N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS 1634-89-5) is a crystalline compound with a molecular weight of approximately 322.29 g/mol. It has a solubility of about 0.02 g/100 mL in water. Chemically, it is a reactive compound, and its reactivity is influenced by its ester and amide functional groups. It is prone to hydrolysis under acidic conditions.

N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS 1634-89-5) is typically synthesized via a multi-step reaction involving coupling of benzyloxycarbonyl chloride with L-glutamic acid. The reaction is catalyzed by an appropriate coupling agent such as HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) and a base like diisopropylethylamine. The yield is generally around 70-80%, with good regioselectivity.

N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS 1634-89-5) is mainly used in the pharmaceutical industry. It serves as a precursor in the synthesis of various bioactive molecules and peptides. Additionally, it can be used in research and development for drug discovery and as a building block in chemical synthesis.

When handling N-[(Benzyloxy)carbonyl]-L-alpha-glutamylglycine (CAS 1634-89-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be carefully cleaned up using appropriate spill kits. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.