Afatinib Impurity 24

Basic Information

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CAS Number

162012-70-6

Molecular Formula

C8H3ClFN3O2

Molecular Weight

227.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

395.3°C at 760 mmHg

Flash Point

193 ºC

Refractive Index

1.673

SMILES

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C1=C2C(=CC(=C1[N+](=O)[O-])F)N=CN=C2Cl

InChI

InChI=1S/C8H3ClFN3O2/c9-8-4-1-7(13(14)15)5(10)2-6(4)11-3-12-8/h1-3H

InChIKey

UYQMNEZWVKRWMS-UHFFFAOYSA-N

LogP

2.85370

Complexity

263

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

UYQMNEZWVKRWMS-UHFFFAOYSA-N
SY027431
162012-70-6
DTXSID60442467
Quinazoline, 4-chloro-7-fluoro-6-nitro-
BCP21434
AKOS015917848
MFCD08063159
nchembio866-comp44
MB05331
A3596
C8H3ClFN3O2
SCHEMBL25409
FT-0650219
AC-8525
4-chloro-7-fluoro-6-nitro quinazoline
J-200171
4-chloro-7-fluoro-6-nitro-quinazoline, AldrichCPR
CS-0000035
4-Chloro-7-fluoro-6-nitro-quinazoline
4-Chloro-7-fluoro-6-nitroquinazoline
4-chloro-7-fluor-6-nitroquinazoline
4-CHLORO-6-NITRO-7-FLUORO-QUINAZOLINE
AS-38865
AM20030091
4-chloro-6-nitro-7-fluoro-quinazoline
QUINAZOLINE,4-CHLORO-7-FLUORO-6-NITRO
4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE###162012-70-6
4-chloro-7-fluoro-6-nitroquinazoline

MDL Number

MFCD08063159

Customs Code

2933990090

FAQ

What are the physical and chemical properties of Afatinib Impurity 24 (CAS: 162012-70-6)?

Afatinib Impurity 24 (CAS: 162012-70-6) is a crystalline solid with a molecular weight of approximately 431.47 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and acetone. Chemically, it is relatively stable under standard laboratory conditions and does not react readily with common reagents. It is recommended to store it under nitrogen to prevent oxidation.

How is Afatinib Impurity 24 (CAS: 162012-70-6) typically synthesized?

Afatinib Impurity 24 (CAS: 162012-70-6) is synthesized through a multi-step process involving key reactions such as alkylation and cyclization. The synthesis typically requires the use of a palladium catalyst and involves multiple purification steps using column chromatography and recrystallization. The overall yield is moderate, and the purity is typically above 95%.

What industries use Afatinib Impurity 24 (CAS: 162012-70-6)?

Afatinib Impurity 24 (CAS: 162012-70-6) is used in the pharmaceutical industry, particularly in the development and quality control of Afatinib, a tyrosine kinase inhibitor used in cancer therapy. It is also relevant in research and development for its role as a byproduct or impurity in the synthesis of Afatinib.

What precautions should be taken when handling Afatinib Impurity 24 (CAS: 162012-70-6)?

When handling Afatinib Impurity 24 (CAS: 162012-70-6), it is important to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate safety procedures, and the material safety data sheet (MSDS) should be consulted for specific guidelines. Storage should be in a cool, dry place away from direct sunlight and ignition sources.