Compound Q&A
How is Afatinib Impurity 24 (CAS: 162012-70-6) typically synthesized?
Answer
Afatinib Impurity 24 (CAS: 162012-70-6) is synthesized through a multi-step process involving key reactions such as alkylation and cyclization. The synthesis typically requires the use of a palladium catalyst and involves multiple purification steps using column chromatography and recrystallization. The overall yield is moderate, and the purity is typically above 95%.
About
CAS No
162012-70-6
English Name
Afatinib Impurity 24
Molecular Formula
C8H3ClFN3O2
Molecular Weight
227.58 g/mol
SMILES
C1=C2C(=CC(=C1[N+](=O)[O-])F)N=CN=C2Cl
InChIKey
UYQMNEZWVKRWMS-UHFFFAOYSA-N
Last Updated: 2025-10-19 13:36
