Afatinib Impurity 48

Basic Information

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CAS Number

162012-69-3

Molecular Formula

C8H4FN3O3

Molecular Weight

209.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

407.6°C at 760 mmHg

Density

1.75

Flash Point

200.3 °C

Refractive Index

1.713

SMILES

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C1=C2C(=CC(=C1[N+](=O)[O-])F)N=CNC2=O

InChI

InChI=1S/C8H4FN3O3/c9-5-2-6-4(1-7(5)12(14)15)8(13)11-3-10-6/h1-3H,(H,10,11,13)

InChIKey

VTUAEMSZEIGQRM-UHFFFAOYSA-N

LogP

1.49360

Complexity

328

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

7-fluoro-6-nitro-1,4-dihydroquinazolin-4-one
MFCD08458874
7-fluoro-6-nitroquinazolin-4-ol
7-Fluoro-6-Nitro-4(H)-Quinazoline
PB14608
AKOS000119293
7-fluoro-6-nitro-3,4-dihydroquinazolin-4-one
MFCD07841697
162012-69-3
DTXSID10427688
AKOS009079807
FD13097
7-fluoro-4-hydroxy-6-nitroquinazoline
EN300-23573
7-fluoro-6-nitro-1H-quinazolin-4-one
CS-B0788
FT-0660825
7-Fluoro-6-nitroquinazolin-4(3H)-one
MB05113
J-009884
A3595
4(3H)-Quinazolinone, 7-fluoro-6-nitro-
VTUAEMSZEIGQRM-UHFFFAOYSA-
InChI=1/C8H4FN3O3/c9-5-2-6-4(1-7(5)12(14)15)8(13)11-3-10-6/h1-3H,(H,10,11,13)
AB00739749-01
GS-4123
VTUAEMSZEIGQRM-UHFFFAOYSA-N
Z154669308
SY027331
AM20030090
7-Fluoro-6-nitro-4-hydroxyquinazoline

MDL Number

MFCD08458874

Customs Code

2933990090

FAQ

What isAfatinib Impurity 48 (CAS: 162012-69-3) ?

Afatinib Impurity 48 (CAS: 162012-69-3) is a byproduct or contaminant identified during the synthesis of Afatinib, a kinase inhibitor used in cancer treatment. It is typically analyzed in pharmaceutical quality control to ensure drug purity. The compound's chemical structure and properties are closely related to Afatinib but may vary slightly, making it critical for regulatory compliance and safety testing in drug development.

What are the main uses of Afatinib Impurity 48 (CAS: 162012-69-3) ?

Afatinib Impurity 48 (CAS: 162012-69-3) is primarily used in pharmaceutical research and quality control to assess the purity of Afatinib. It also aids in understanding degradation pathways during drug stability testing. Additionally, it serves as a reference standard in analytical methods to identify impurities in drug manufacturing processes.

Is Afatinib Impurity 48 (CAS: 162012-69-3) safe ?

Afatinib Impurity 48 (CAS: 162012-69-3) is not intended for human or animal use and should be handled with care. Safety data indicates potential toxicity upon prolonged exposure, necessitating proper protective equipment and ventilation. It is crucial to follow established safety protocols to minimize risks during laboratory handling and storage.

How should Afatinib Impurity 48 (CAS: 162012-69-3) be stored ?

Afatinib Impurity 48 (CAS: 162012-69-3) should be stored in a sealed, light-resistant container at controlled room temperature (15-25°C) or refrigerated conditions (2-8°C) to maintain stability. Keep it away from moisture and heat sources. Proper storage ensures minimal degradation and adherence to safety standards for handling and use.