Deruxtecan | CAS No. 1599440-13-7

Deruxtecan

Basic Information

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CAS Number

1599440-13-7

Molecular Formula

C52H56FN9O13

Molecular Weight

1034.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5cc(c(c6c5c4[C@H](CC6)NC(=O)COCNC(=O)CNC(=O)[C@H](Cc7ccccc7)NC(=O)CNC(=O)CNC(=O)CCCCCN8C(=O)C=CC8=O)C)F)O

InChI

InChI=1S/C52H56FN9O13/c1-3-52(73)33-19-38-48-31(24-62(38)50(71)32(33)25-75-51(52)72)47-35(14-13-30-28(2)34(53)20-36(60-48)46(30)47)58-43(67)26-74-27-57-41(65)22-56-49(70)37(18-29-10-6-4-7-11-29)59-42(66)23-55-40(64)21-54-39(63)12-8-5-9-17-61-44(68)15-16-45(61)69/h4,6-7,10-11,15-16,19-20,35,37,73H,3,5,8-9,12-14,17-18,21-27H2,1-2H3,(H,54,63)(H,55,64)(H,56,70)(H,57,65)(H,58,67)(H,59,66)/t35-,37-,52-/m0/s1

InChIKey

WXNSCLIZKHLNSG-MCZRLCSDSA-N

LogP

0.28242000000000994

Topological Polar Surface Area

302.63 Å²

Hydrogen Bond Donor/Acceptor

7 / 22

Complexity

2360

Synonyms & References

English

Deruxtecan
5SEB972CO4
Deruxtecan [USAN]
Mc-ggfg-dxd(1)
N-(6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)glycylglycyl-L-phenylalanyl-

MDL Number

MFCD31657445

FAQ

What is Deruxtecan (CAS: 1599440-13-7)?

Deruxtecan is a novel antibody-drug conjugate (ADC) used in cancer therapy. It consists of an anti-nectin-4 antibody linked to a potent topoisomerase I inhibitor. Deruxtecan has a molecular weight of approximately 12,000 Da and is designed for targeted delivery of chemotherapy to nectin-4-expressing tumors.

What are the main uses of Deruxtecan (CAS: 1599440-13-7)?

Deruxtecan is primarily used as a treatment for patients with advanced or metastatic solid tumors, particularly those expressing the nectin-4 antigen. It is approved for use in certain types of breast cancer, lung cancer, and other cancers. Deruxtecan is administered intravenously and acts by selectively delivering cytotoxic payload to cancer cells expressing nectin-4.

Is Deruxtecan (CAS: 1599440-13-7) safe?

Deruxtecan is generally considered safe when used under medical supervision. However, it can cause side effects such as nausea, fatigue, and diarrhea. Patients should be monitored closely, and appropriate precautions should be taken to manage potential adverse reactions. Always consult with a healthcare professional regarding the safety of Deruxtecan.

How should Deruxtecan (CAS: 1599440-13-7) be stored?

Deruxtecan should be stored in a refrigerator at 2°C to 8°C (36°F to 46°F) and protected from light. It must be kept in its original container to maintain its stability. Avoid freezing and ensure that the product is not exposed to excessive heat or humidity. Store it out of reach of children and in a secure location to prevent accidental exposure or misuse.