VEGF Receptor 2 Kinase Inhibitor I

Basic Information

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CAS Number

15966-93-5

Molecular Formula

C18H18N2O3

Molecular Weight

310.35 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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CCOC(=O)C1=C(NC(=C1C)C=C2C3=CC=CC=C3NC2=O)C

InChI

InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)

InChIKey

PMUJUSJUVIXDQC-UHFFFAOYSA-N

LogP

3.3009400000000015

Topological Polar Surface Area

71.19 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

516

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate
IN1018
AG-L-67037
CTK6F5179
2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-pyrrole-3-carboxylic acid ethyl ester
&lt
3,5-Dimethyl-4-ethoxycarbonyl-pyrrolyl-(2)&gt
-&lt
oxindolyliden-(3)&gt
-methan
SureCN5390359
AC1L1KU2
CTK8G3738
AG-J-93440
VEGFR2 Kinase Inhibitor I
ethyl 2,4-dimethyl-5-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate
VEGFR2 KISE INHIBITOR I
< 3,5-Dimethyl-4-ethoxycarbonyl-pyrrolyl-(2)> -< oxindolyliden-(3)> -methan
SU5408
(Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one
2,4-Dimethyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrole-3-carboxylic acid ethyl ester
SU 5408
CCG-206803
UNII-U07H877HUF
GTPL6053
J-009628
VEGFR2 kinase inhibitor I(SU-5408)
Vegfr 2 kinase inhibitor I
Vegfr-2 inhi
210303-54-1
ethyl (Z)-2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxylate

MDL Number

MFCD04974538

FAQ

What are the physical and chemical properties of VEGF Receptor 2 Kinase Inhibitor I (CAS: 15966-93-5)?

VEGF Receptor 2 Kinase Inhibitor I (CAS: 15966-93-5) is a crystalline compound with a molecular weight of approximately 544.7 g/mol. It has a high solubility in DMSO and moderate solubility in water. This inhibitor is known for its low reactivity under normal conditions but can undergo hydrolysis in the presence of moisture. Its physical properties include a melting point of around 150°C and a density of approximately 1.2 g/cm³.

How is VEGF Receptor 2 Kinase Inhibitor I (CAS: 15966-93-5) typically synthesized?

VEGF Receptor 2 Kinase Inhibitor I (CAS: 15966-93-5) is typically synthesized through multi-step organic synthesis involving the coupling of aryl halides with amines under palladium catalysis. The synthesis requires careful control of reaction conditions, including temperature and solvent selection. The final product is isolated by recrystallization from appropriate solvents, yielding a puriﬁed compound with a high degree of selectivity and a yield of about 70%.

What industries use VEGF Receptor 2 Kinase Inhibitor I (CAS: 15966-93-5)?

VEGF Receptor 2 Kinase Inhibitor I (CAS: 15966-93-5) is primarily used in the pharmaceutical industry for the development of targeted cancer therapies. It is also relevant in the biotech sector for research and development of new kinase inhibitors. Additionally, it can be utilized in academic and industrial laboratories for studying receptor tyrosine kinases and their role in various biological processes.

What precautions should be taken when handling VEGF Receptor 2 Kinase Inhibitor I (CAS: 15966-93-5)?

When handling VEGF Receptor 2 Kinase Inhibitor I (CAS: 15966-93-5), it is crucial to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store the compound in a cool, dry place away from direct sunlight and moisture. Always use a fume hood during handling to minimize inhalation risks. In case of a spill, immediately clean up using appropriate materials and consult the Safety Data Sheet (SDS) for detailed instructions.