2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate

Basic Information

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CAS Number

157634-00-9

Molecular Formula

C11H21NO3

Molecular Weight

215.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

74-78 °C

Boiling Point

308℃ at 760 mmHg

Flash Point

140.1℃

SMILES

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CC(C)(C)OC(=O)N1CCCCC1CO

InChI

InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-7-5-4-6-9(12)8-13/h9,13H,4-8H2,1-3H3

InChIKey

PZTAGFCBNDBBFZ-UHFFFAOYSA-N

LogP

1.7683

Topological Polar Surface Area

49.769999999999996 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

222

Safety Information

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GHS Hazard Pictograms

H301

H315

H319

H335

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

N-Boc-piperidine-2-methanol
MFCD04114966
EN300-50678
1-(tert-Butoxycarbonyl)-2-piperidinemethanol
Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester
BCP16885
1-Boc-2-(hydroxymethyl)piperidine
157634-00-9
FT-0645157
dipropyleneglycoldibenzoate
MFCD04973121
PZTAGFCBNDBBFZ-UHFFFAOYSA-N
F0001-0561
1-Tert-butoxycarbonyl-2-piperidinemethanol,2-Hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester, N-Boc-2-(hydroxymethyl)piperidine
1-Boc-2-Piperidinemethanol
DTXSID30377171
SY006184
AB19346
FT-0649913
tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate
1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperidine
SY018938
3X-0727
TERT-BUTYL 2-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
SCHEMBL282976
A3465
2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester
AB21261
1-Boc-Piperidine-2-Methanol
SY006185
1-Boc-2-Hydroxymethyl-piperidine

MDL Number

MFCD04114966

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 157634-00-9)?

2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 157634-00-9) is a colorless to white crystalline solid with a molecular weight of approximately 221.29 g/mol. It has a low solubility in water but is soluble in organic solvents such as methanol and acetone. The compound is known for its reactivity in esterification and amidation reactions, making it useful in organic synthesis.

How is 2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 157634-00-9) typically synthesized?

2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 157634-00-9) can be synthesized through an amidation reaction of 2-(hydroxymethyl)-1-piperidinecarboxylic acid with 2-methyl-2-propanol. This reaction typically requires a base like sodium hydride as a catalyst. The yield is usually high, and the product is isolated by recrystallization from an appropriate solvent.

What industries use 2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 157634-00-9)?

2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 157634-00-9) is primarily used in the pharmaceutical industry for the synthesis of various medicaments. It also finds applications in the production of polymers and as a building block in organic chemistry for developing new materials and reagents.

What precautions should be taken when handling 2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 157634-00-9)?

When handling 2-Methyl-2-propanyl 2-(hydroxymethyl)-1-piperidinecarboxylate (CAS: 157634-00-9), it is important to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.