Rosiglitazone maleate

Basic Information

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CAS Number

155141-29-0

Molecular Formula

C22H23N3O7S

Molecular Weight

473.51 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

235-240 ºC

Boiling Point

585°C at 760 mmHg

Flash Point

307.6ºC

SMILES

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CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O

InChI

InChI=1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

SUFUKZSWUHZXAV-BTJKTKAUSA-N

LogP

2.2026999999999997

pKa

6.1; 6.8(at 25℃)

Topological Polar Surface Area

146.13 Å²

Hydrogen Bond Donor/Acceptor

3 / 10

Complexity

588

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MLS001306472
Nyracta
CAS-155141-29-0
ROSIGLITAZONE MALEATE [MART.]
BR164376
Rosiglitzazone maleate
ROSIGLITAZONE MALEATE [JAN]
(+/-)-5-(P-(2-(METHYL-2-PYRIDYLAMINO)ETHOXY)BENZYL)-2,4-THIAZOLIDINEDIONE MALEATE (1:1)
ROSIGLITAZONE MALEATE [MI]
Avandia
BRL 49653C
SW197573-4
(+/-)-5-((4-(2-(Methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione, (Z)-2-Butenedioate (1:1)
1217260-35-9
HB4140
Rosiglitazone maleate (JAN/USP)
NS00076223
BRL 49653-C
ROSIGLITAZONE MALEATE (MART.)
5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleate
NSC717764
155141-29-0
2, 5-[[4-[2-(methyl-2-pyridinylamino) ethoxy]phenyl]methyl]-, (2Z)-2-butenedioate (1:1)
(Z)-but-2-enedioate;2-[4-[(2,4-dioxo-1,3-thiazolidin-3-ium-5-yl)methyl]phenoxy]ethyl-methyl-pyridin-2-ylazanium
D00596
CHEMBL843
AC-737
HMS3884H04
CHEBI:8892
AKOS015961534
5-(p-(2-(Methyl-2-pyridylamino)ethoxy)benzyl)-2,4-thiazolidinedione monomaleate

MDL Number

MFCD03427306

FAQ

What is Rosiglitazone maleate (CAS: 155141-29-0)?

Rosiglitazone maleate is a synthetic compound used primarily in pharmaceutical applications. It has the chemical formula C22H26N2O5S and is a white to pale yellow crystalline powder. The compound is known for its solubility in water and organic solvents, and it is commonly used as an active pharmaceutical ingredient in the treatment of type 2 diabetes.

What are the main uses of Rosiglitazone maleate (CAS: 155141-29-0)?

Rosiglitazone maleate is mainly used as a medication for managing type 2 diabetes. It works by improving insulin sensitivity in muscle and fat tissues. Additionally, it is used in research for studying metabolic disorders and in the pharmaceutical industry for drug development and formulation.

Is Rosiglitazone maleate (CAS: 155141-29-0) safe?

Rosiglitazone maleate is generally considered safe when used as directed, but it may have side effects such as fluid retention and increased risk of heart failure. It is important to follow proper handling precautions and consult a healthcare professional for appropriate use. Safety standards ensure its quality and purity for medicinal purposes.

How should Rosiglitazone maleate (CAS: 155141-29-0) be stored?

Rosiglitazone maleate should be stored in a cool, dry place away from light. It is typically kept in airtight containers at a temperature below 25°C and humidity levels below 60%. Proper storage ensures its stability and effectiveness over time.