1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine

Basic Information

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CAS Number

154212-60-9

Molecular Formula

C8H14N2S

Molecular Weight

170.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

230.9±15.0°C at 760 mmHg

SMILES

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CC(C)C1=NC(=CS1)CNC

InChI

InChI=1S/C8H14N2S/c1-6(2)8-10-7(4-9-3)5-11-8/h5-6,9H,4H2,1-3H3

InChIKey

HWSFABGWAXURNG-UHFFFAOYSA-N

LogP

1.9859

Topological Polar Surface Area

24.92 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

117

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SB17857
1-(2-isopropylthiazol-4-yl)-N-methyl-methanamine;2-Isopropyl-4-(methylaminomethyl)thiazole
DS-1931
4-Thiazolemethanamine, N-methyl-2-(1-methylethyl)-
A809508
2-Isopropyl-4-(methylaminomethyl) thiazole
CHEMBL4563202
Q27278645
G297848J78
2-Isopropyl-4-(N-methylaminomethyl)thiazole
FT-0643514
FS-3490
[(2-ISOPROPYL-1,3-THIAZOL-4-YL)METHYL](METHYL)AMINE
2-isopropyl-4-(methylaminomethyl)thiazole
2-Isopropyl-4-(((N-methyl)amino)methyl)thiazole
2-isopropyl-4-(((N-methyl)amino)-methyl)thiazole
N-Methyl-2-isopropyl-4-thiazolemethylamine
AKOS010300418
methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})amine
HWSFABGWAXURNG-UHFFFAOYSA-N
MFCD06797969
DTXSID20165569
1-(2-Isopropyl-4-thiazolyl)-N-methylmethanamine
UNII-G297848J78
SY019475
AM84496
2-Isopropyl-4-(N-methyl)amino-methyl thiazole
EN300-257001
BDBM626122
154212-60-9
2-isopropyl-4-(n-methyl)aminomethylthiazole

MDL Number

MFCD06797969

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine (CAS: 154212-60-9)?

1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine is a crystalline compound with a molecular weight of approximately 249.31 g/mol. It has a low water solubility, around 0.1 g/L at 25°C. In terms of reactivity, it is relatively stable but can undergo nucleophilic substitution reactions. Its chemical structure includes a thiazole ring, which contributes to its unique reactivity and stability.

How is 1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine (CAS: 154212-60-9) typically synthesized?

1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine can be synthesized through a multistep process involving the protection of an amine, subsequent coupling, and finally, deprotection. Typically, this involves using a protecting group such as BOC (tert-butoxycarbonyl) to react with a thiazole derivative, followed by a coupling reaction with a methylamine derivative. The reaction is often carried out in an organic solvent at room temperature. High purity can be achieved with a yield of up to 85%.

What industries use 1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine (CAS: 154212-60-9)?

1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine finds application in the pharmaceutical industry as an intermediate for the synthesis of drugs. It is also used in the polymer industry for the modification of polymers, and in the semiconductor industry for the production of functional materials. Additionally, it is employed in the sensor industry for the development of gas sensors due to its reactivity with certain analytes.

What precautions should be taken when handling 1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine (CAS: 154212-60-9)?

When handling 1-(2-Isopropyl-1,3-thiazol-4-yl)-N-methylmethanamine, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal procedures.