2-Fluoro-3-iodo-5-methylpyridine

Basic Information

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CAS Number

153034-78-7

Molecular Formula

C6H5FIN

Molecular Weight

237.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

No data available

Melting Point

38-42 °C

Boiling Point

252.5℃ at 760 mmHg

Density

1.0000

SMILES

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CC1=CC(=C(N=C1)F)I

InChI

InChI=1S/C6H5FIN/c1-4-2-5(8)6(7)9-3-4/h2-3H,1H3

InChIKey

ANOOZLFFCNANTR-UHFFFAOYSA-N

LogP

2.1337200000000003

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

99.1

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Synonyms & References

English

SY022310
PS-7630
153034-78-7
AKOS008901113
FT-0657445
2-Fluoro-3-iodo-5-picoline
CS-0007510
2-Fluoro-3-iodo-5-methylpyridine
AM803254
ANOOZLFFCNANTR-UHFFFAOYSA-N
Pyridine, 2-fluoro-3-iodo-5-methyl-
MFCD03095303
SCHEMBL622619
DS-0826
2-Fluoro-3-iodo-5-picoline (2-Fluoro-3-iodo-5-methylpyridine)
2-fluoro-3-iodo-5-methylpyridine, 95%
EN300-198460
2-Fluoro-3-iodo-5-methylpyridine, AldrichCPR
AC-33390
A1-25132
DTXSID30437229
2-fluoro-3-iodo-5-methyl-pyridine
A3360
2-FLUORO-3-IODO-5-PICOLINE
2-fluoro-3-iodo-5-fluoropyridine
2-FLUORO-3-IODO-5-PICOLINE (2-FLUORO-3-IODO-5-METHYLPYRIDINE)
2,5-difluoro-3-iodopyridine
2-Fluoro-3-iodo-5-picolin
2-fluoro-3-iodo-5-methylpyridine

MDL Number

MFCD03095303

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Fluoro-3-iodo-5-methylpyridine (CAS: 153034-78-7)?

2-Fluoro-3-iodo-5-methylpyridine is a crystalline solid with a molecular weight of approximately 268.02 g/mol. It has limited water solubility and is soluble in organic solvents like ethanol and dichloromethane. This compound is known for its low reactivity under normal conditions but can be sensitive to air and moisture. It is used in various synthetic applications and should be handled in a fume hood.

How is 2-Fluoro-3-iodo-5-methylpyridine (CAS: 153034-78-7) typically synthesized?

2-Fluoro-3-iodo-5-methylpyridine can be synthesized via the iodination of 2-fluoro-5-methylpyridine using N-iodosuccinimide (NIS) as an oxidizing agent in the presence of a base like sodium hydride. The reaction typically yields high selectivity and good to excellent yields, depending on the conditions.

What industries use 2-Fluoro-3-iodo-5-methylpyridine (CAS: 153034-78-7)?

2-Fluoro-3-iodo-5-methylpyridine is primarily used in pharmaceutical research, where it serves as a key intermediate in the synthesis of various drugs. It is also used in the development of materials for sensors and semiconductors due to its unique electronic properties.

What precautions should be taken when handling 2-Fluoro-3-iodo-5-methylpyridine (CAS: 153034-78-7)?

When handling 2-Fluoro-3-iodo-5-methylpyridine, it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area, and all reactions should be performed in a fume hood. In case of a spill, neutralize the area with water and notify safety personnel. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.