Sevelamer hydrochloride

Basic Information

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CAS Number

152751-57-0

Molecular Formula

C6H13Cl2NO

Molecular Weight

186.08 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

116.1ºC at 760 mmHg

Flash Point

33.9ºC

SMILES

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C=CCN.C1C(O1)CCl.Cl

InChI

InChI=1S/C3H5ClO.C3H7N.ClH/c4-1-3-2-5-3;1-2-3-4;/h3H,1-2H2;2H,1,3-4H2;1H

InChIKey

KHNXRSIBRKBJDI-UHFFFAOYSA-N

LogP

1.1768999999999998

Topological Polar Surface Area

38.55 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

55.1

Synonyms & References

English

BCP21176
AKOS025149504
2-(chloromethyl)oxirane;prop-2-en-1-amine;hydrochloride
Sevelamer hydrochloride (JAN/USAN)
HS-0082
152751-57-0
Sevelamer hydrochloride
Sevelamer HCl
2-Propen-1-amine, hydrochloride (1:1), polymer with 2-(chloromethyl)oxirane
182683-00-7
CHEBI:32127
2-Propen-1-amine Hydrochloride polymer with (Chloromethyl)oxirane
s4129
KHNXRSIBRKBJDI-UHFFFAOYSA-N
F85037
CGA75157
D01983
AB01568265_01
AC-2089
FT-0653684
SEVELAMER HCL
Sevelemar
Sevelamer Hydrochloride
2-Propen-1-amine polymer with (chloromethyl)oxirane hydrochloride
Sevelamer Hydrochlor
Sevelamer Hydrochloride (Technical Grade)
Sevelamer HydrochlorideDISCONTINUED See : S256000
Sevelamer (hydrochloride)
SevelaMer HCL API
AllylaMine Hydrochloride-epichlorohydrin CopolyMer
(ChloroMethyl)oxirane polyMer with 2-Propen-1-aMine Hydrochloride

MDL Number

MFCD09260188

FAQ

What are the physical and chemical properties of Sevelamer hydrochloride (CAS: 152751-57-0)?

Sevelamer hydrochloride (CAS: 152751-57-0) is a white crystalline powder. It has a molecular weight of approximately 243.59 g/mol. This compound is poorly soluble in water and organic solvents. It exhibits low reactivity and is stable under normal conditions, making it suitable for pharmaceutical applications.

How is Sevelamer hydrochloride (CAS: 152751-57-0) typically synthesized?

Sevelamer hydrochloride is typically synthesized by reacting sevelamer with hydrochloric acid. The process involves the condensation of sevelamer with HCl under mild conditions, resulting in a high yield and good selectivity. The product is then purified by crystallization.

What industries use Sevelamer hydrochloride (CAS: 152751-57-0)?

Sevelamer hydrochloride (CAS: 152751-57-0) is primarily used in the pharmaceutical industry. It is approved for the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis. It is also used in biomedical applications such as drug delivery systems and in the preparation of certain pharmaceutical formulations.

What precautions should be taken when handling Sevelamer hydrochloride (CAS: 152751-57-0)?

When handling Sevelamer hydrochloride (CAS: 152751-57-0), it is important to wear appropriate personal protective equipment (PPE), including gloves and eye protection. The material should be handled in a well-ventilated area or a fume hood. In case of a spill, the area should be cleaned up immediately, and the appropriate safety data sheet (SDS) should be consulted for detailed instructions.