Sapacitabine | CAS No. 151823-14-2

Sapacitabine

Basic Information

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CAS Number

151823-14-2

Molecular Formula

C26H42N4O5

Molecular Weight

490.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

°Cat760mmHg

Density

1.21

Refractive Index

1.574

SMILES

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CCCCCCCCCCCCCCCC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)C#N

InChI

InChI=1S/C26H42N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-23(32)28-22-16-17-30(26(34)29-22)25-20(18-27)24(33)21(19-31)35-25/h16-17,20-21,24-25,31,33H,2-15,19H2,1H3,(H,28,29,32,34)/t20-,21+,24-,25+/m0/s1

InChIKey

LBGFKUUHOPIEMA-PEARBKPGSA-N

LogP

4.549800000000005

Topological Polar Surface Area

113.68 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

775

Synonyms & References

English

HY-16445
DTXSID90164887
Sapacitabine (CYC682)
CYC 682
N-(1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl)hexadecanamide
PCNDAC
Sapacitabine [USAN:INN]
UNII-W335P73C3L
W335P73C3L
NSC-791785
CYC682
LBGFKUUHOPIEMA-PEARBKPGSA-N
SAPACITABINE [INN]
NSC791785
SAPACITABINE [WHO-DD]
HEXADECANAMIDE, N-(1-(2-CYANO-2-DEOXY-.BETA.-D-ARABINOFURANOSYL)-1,2-DIHYDRO-2-OXO-4- PYRIMIDINYL)-
sapacitabinum
N-[1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-2-oxo-1,2-dihydropyrimidine-4-yl]hexadecanamide
NS00071064
D09722
Q7420893
CHEBI:145429
Hexadecanamide, N-(1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl)-
CHEMBL2105681
SAPACITABINE [USAN]
SCHEMBL711854
CS-0006340
Sapacitabine
2'-C-cyano-2'-deoxy-1-arabinofuranosyl-N(4)-palmitoylcytosine
1-(2-cyano-2-deoxy-beta-D-arabinofuranosyl)-4-(hexadecanoylamino)pyrimidin-2(1H)-one
DB06365

MDL Number

MFCD00919466

FAQ

What regulatory guidelines apply to Sapacitabine (CAS: 151823-14-2)?

Sapacitabine (CAS: 151823-14-2) falls under the regulatory guidelines of the Chemicals in the European Union (REACH) and the United States Environmental Protection Agency (EPA). For pharmaceutical purposes, it also adheres to FDA requirements for drug substances and products. It is recommended to consult the latest GHS (Globally Harmonized System of Classification and Labeling of Chemicals) for accurate hazard classification and labeling.

Are there alternatives to Sapacitabine (CAS: 151823-14-2) in synthesis?

While Sapacitabine (CAS: 151823-14-2) is a specific and effective drug, alternatives in terms of nucleoside analogs for similar biological activity include other cytidine analogs such as clofarabine and fludarabine. These can serve as substitutes depending on the specific synthesis route and desired properties.

What is the market or research trend for Sapacitabine (CAS: 151823-14-2)?

Sapacitabine (CAS: 151823-14-2) is primarily used in oncology for the treatment of acute myeloid leukemia. Market trends indicate increasing research interest in its efficacy and safety, particularly in combination therapies. Studies are also exploring its potential in other hematological cancers. The trend suggests a steady market demand with ongoing clinical trials.

How should waste containing Sapacitabine (CAS: 151823-14-2) be handled?

Waste containing Sapacitabine (CAS: 151823-14-2) should be collected in appropriate containers and stored separately. For disposal, it is recommended to follow local hazardous waste regulations, which may include incineration or professional waste disposal services. Ensure all disposal methods comply with REACH and GHS guidelines to minimize environmental impact and ensure safety during handling and transportation.