Folinic acid calcium

Basic Information

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CAS Number

1492-18-8

Molecular Formula

C20H21CaN7O7

Molecular Weight

511.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

195°C

Boiling Point

°Cat760mmHg

Density

1.2230

Vapor Pressure

No data available

SMILES

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C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Ca+2]

InChI

InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChIKey

KVUAALJSMIVURS-ZEDZUCNESA-L

LogP

1.41100

Complexity

900

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Sensitization, respiratory

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
Calcium L-folinate
EN300-6735051
Folinate de calcium (INN-French)
A808865
Folinic acid-SF, calcium salt
Leucovorin calcium [USP]
Folinicacid
Calcii folinas [INN-Latin]
BDBM50247893
N-(4-(((2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amnio)benzoyl)-L-glutamic Acid, Calcium Salt (1:1)
CALCIUM FOLINATE [MART.]
CCG-269782
Calcium folinate [INN]
CALCIUM FOLINATE [EP IMPURITY]
Folinato calcico (INN-Spanish)
CS-1363
Calc Folinate
Folix
FOLI-cell
Folinoral
Folidar
folinic acid calcium
L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1)
LEUCOVORIN CALCIUM [USP MONOGRAPH]
BC164621
Folinic acid calcium salt hydrate
Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1), L-
LEUCOVORIN CALCIUM (USP MONOGRAPH)
LEUCOVORIN CALCIUM [VANDF]
Cromatonbic Folinico

MDL Number

MFCD00006704

Customs Code

2942000000

FAQ

What is Folinic acid calcium (CAS: 1492-18-8)?

Folinic acid calcium (CAS: 1492-18-8) is a calcium salt of folinic acid, a reduced form of folic acid. Its chemical formula is C19H20N4O9Ca, and it appears as a white crystalline powder. It is highly soluble in water and serves as a key folate precursor in pharmaceutical and nutritional applications, supporting DNA synthesis and cellular function.

What are the main uses of Folinic acid calcium (CAS: 1492-18-8)?

Folinic acid calcium (CAS: 1492-18-8) is primarily used in pharmaceuticals to treat folate deficiency, particularly in patients undergoing methotrexate therapy. It functions as a nutritional supplement to enhance folate intake and is also employed in research for studying folate metabolism. Additionally, it may be used in food fortification to improve vitamin B9 content.

Is Folinic acid calcium (CAS: 1492-18-8) safe?

Folinic acid calcium (CAS: 1492-18-8) is generally safe when used as directed, with low toxicity in normal doses. However, ingestion of large amounts may cause gastrointestinal discomfort. It adheres to safety standards for pharmaceutical and food applications, and proper handling, such as avoiding direct contact with skin or eyes, ensures safe use in both industrial and research settings.

How should Folinic acid calcium (CAS: 1492-18-8) be stored?

Folinic acid calcium (CAS: 1492-18-8) should be stored in a cool, dry place (20-25°C) away from moisture and light. Keep in airtight containers to maintain stability and prevent degradation. Avoid exposure to incompatible substances and store in a desiccator if humidity control is necessary for long-term preservation.