N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine

Basic Information

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CAS Number

148515-78-0

Molecular Formula

C25H23NO6

Molecular Weight

433.46 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Solubility

Insuluble (7.8E-3 g/L) (25 ºC),

SMILES

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COC1=CC(=C(C=C1)CN(CC(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)O

InChI

InChI=1S/C25H23NO6/c1-31-16-11-10-15(23(27)13-16)12-22(24(28)29)26-25(30)32-14-21-19-8-4-2-6-17(19)18-7-3-5-9-20(18)21/h2-11,13,21-22,27H,12,14H2,1H3,(H,26,30)(H,28,29)/t22-/m0/s1

InChIKey

QNNSINGLLJSINC-QFIPXVFZSA-N

LogP

3.935200000000002

Topological Polar Surface Area

105.09000000000002 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

634

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-N-[(2-hydroxy-4-methoxyphenyl)methyl]glycine
PD197178
Fmoc-N-(2-hydroxy-4-methoxy-Bzl)-Gly-OH
FD21609
N-Fmoc-N-(2-hydroxy-4-methoxybenzyl)glycine
148515-78-0
CS-0101843
Fmoc-(Hmb)Gly-OH
DTXSID00653838
Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-[(2-hydroxy-4-methoxyphenyl)methyl]-
HY-W047845
Fmoc-N-(2-hydroxy-4-methoxy-benzyl)-Gly-OH
Glycine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-[(2-hydroxy-4-methoxyphenyl)methyl]-
MFCD06796005
SY102653
AKOS025289438
Fmoc-N(Hmb)-Gly-OH
2-[9H-fluoren-9-ylmethoxycarbonyl-[(2-hydroxy-4-methoxyphenyl)methyl]amino]acetic acid
A884351
N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(2-hydroxy-4-methoxybenzyl)glycine
S-148515-78-0
Fmoc-N-(Hmb)-Gly-OH
J-008478
DS-7545
Fmoc-HMB-Gly-OH
{[(9H-fluoren-9-ylmethoxy)carbonyl][(2-hydroxy-4-methoxyphenyl)methyl]amino}acetic acid
FMOC-(HMB)GLY-OH
(9H-Fluoren-9-yl)MethOxy]Carbonyl N(Hmb)-Gly-OH
N-ALPHA-FMOC-N-ALPHA-(2-HYDROXY-4-METHOXYBENZYL)GLYCINE
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-(2-HYDROXY-4-METHOXY-BENZYL)-GLYCINE
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-[(2-hydroxy-4-methoxyphenyl)methyl]glycine

MDL Number

MFCD06796005

FAQ

What are the physical and chemical properties of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine (CAS: 148515-78-0)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine (CAS: 148515-78-0) is a white crystalline solid with a molecular weight of approximately 535 g/mol. It is slightly soluble in water and moderately soluble in organic solvents. This compound is known for its stability and reactivity in esterification reactions. It is used as a chiral building block in the synthesis of pharmaceuticals and natural product analogues.

How is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine (CAS: 148515-78-0) typically synthesized?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine (CAS: 148515-78-0) is synthesized through a multi-step process. Starting material is fluoren-9-ylmethanol, which undergoes acylation to form the fluoren-9-ylmethoxy carbonyl. This intermediate is then coupled with 2-hydroxy-O-methyl-L-tyrosine in the presence of a suitable catalyst to yield the desired product. The reaction typically provides high yield and good purity.

What industries use N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine (CAS: 148515-78-0)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine (CAS: 148515-78-0) is primarily used in the pharmaceutical industry for the synthesis of chiral intermediates and drugs. It is also used in the research and development of natural product analogues and in various applications including polymers and sensors.

What precautions should be taken when handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine (CAS: 148515-78-0)?

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-hydroxy-O-methyl-L-tyrosine (CAS: 148515-78-0), it is important to wear appropriate personal protective equipment (PPE), including gloves and eye protection. The compound should be stored in a cool, dry place away from sources of heat and light. In case of spills, they should be cleaned up immediately using appropriate safety measures, and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.