Azilsartan | CAS No. 147403-03-0

Azilsartan

Basic Information

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CAS Number

147403-03-0

Molecular Formula

C25H20N4O5

Molecular Weight

456.46 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

No data available

Boiling Point

No data available

Flash Point

No data available

Solubility

DMSO: soluble15mg/mL (clear solution)

SMILES

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CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O

InChI

InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)

InChIKey

KGSXMPPBFPAXLY-UHFFFAOYSA-N

LogP

4.191800000000002

Topological Polar Surface Area

123.24000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

783

Safety Information

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GHS Hazard Pictograms

H361

Hazard Statement

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Synonyms & References

English

CHEBI:68850
FT-0662457
BA164233
UNII-F9NUX55P23
TAK 536
Azilsartan [USAN:INN]
Azilsartan, >=98% (HPLC)
Azilva (TN)
F9NUX55P23
NS00004259
2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
Azilsartan- Bio-X
AM84439
EN300-6482027
1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl) [1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid
AZILSARTAN [WHO-DD]
AC-25912
2-Ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)- 1H-benzimidazole-7-carboxylic acid
Z1575099375
2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid
1H-Benzimidazole-7-carboxylic acid, 1-((2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol- 3-yl)(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-
CHEMBL57242
KGSXMPPBFPAXLY-UHFFFAOYSA-N
SB20804
HSDB 8208
AZILSARTAN [JAN]
TAK-536
AB01566867_01
SCHEMBL167538
MFCD00916395

MDL Number

MFCD20278186

FAQ

What is Azilsartan (CAS: 147403-03-0)?

Azilsartan (CAS: 147403-03-0) is an angiotensin II receptor blocker (ARB) used in pharmaceuticals. Its chemical formula is C19H21N5O3S, and it is a white crystalline powder with high solubility in DMSO. It works by inhibiting angiotensin II activity, making it effective for managing hypertension and cardiovascular conditions.

What are the main uses of Azilsartan (CAS: 147403-03-0)?

Azilsartan (CAS: 147403-03-0) is primarily used as a hypertension treatment, reducing blood pressure by blocking angiotensin II receptors. It is an active ingredient in medications like CoAprovel, aiding in cardiovascular health management. Additionally, it is used in research for studying ARB mechanisms and in drug development for related therapies.

Is Azilsartan (CAS: 147403-03-0) safe?

Azilsartan (CAS: 147403-03-0) is generally safe when used as directed, with low toxicity in therapeutic doses. Common side effects may include dizziness or dry cough, but severe reactions are rare. Proper handling, including personal protective equipment (PPE), is recommended during storage and use to ensure safety standards are met.

How should Azilsartan (CAS: 147403-03-0) be stored?

Azilsartan (CAS: 147403-03-0) should be stored in a cool, dry place (20-25°C) away from light and moisture. Keep in a sealed container to maintain stability and prevent degradation. Avoid exposure to high humidity or extreme temperatures to ensure long-term storage and efficacy.