Rosuvastatin Calcium

Basic Information

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CAS Number

147098-20-2

Molecular Formula

C44H54CaF2N6O12S2

Molecular Weight

1001.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

160°C

Boiling Point

745.6°C at 760 mmHg

Density

Flash Point

404.7 °C

Specific Rotation

+14-+16° (c=1.01, 50% MeOH)

SMILES

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CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C.[Ca+2]

InChI

InChI=1S/2C22H28FN3O6S.Ca/c2*1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h2*5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;;+2/p-2/b2*10-9+;/t2*16-,17-;/m11./s1

InChIKey

LALFOYNTGMUKGG-BGRFNVSISA-L

LogP

4.29560

Complexity

761

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

D01915
Rosuvastatin calcium (JAN/USAN)
calcium(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
AKOS005145896
SCHEMBL429217
ZD-4522 (Calcium salt)
ROSUVASTATIN CALCIUM (EP MONOGRAPH)
(S-(R*,S*-(E)))-7-(4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1)
Q27146836
ROSUVASTATIN CALCIUM COMPONENT OF ROSZET
Crestor (TN)
BIS((E)-7-(4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(METHYL(METHYLSULFONYL)AMINO)-PYRIMIDE-5-YL)-(3R,5S)3,5-DIHYDROXYLHEPT-6-ENOIC ACID) CALCIUM
KS-1109
ROSUVASTATIN CALCIUM [EP MONOGRAPH]
Provisacor
6-Heptenoic acid, 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)
Rosuvastatin (as calcium)
Rovista
Fortius
ZD 4522 Calcium
s2169
Crestor
Monocalcium bis((3R,5S,6E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl(methyl)amino)pyrimidin-5-yl)-3,5-dihydroxyept-6-enoate)
AZD-4522
(S-((R*,S*-(E)))- 7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1)
ROSUVASTATIN CALCIUM [USP MONOGRAPH]
calcium;(E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
CCG-270606
(S-((R*,S*-(E)))-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl) amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid, calcium salt (2:1)
Suvikan
S-4522

MDL Number

MFCD04112702

Customs Code

2935009090

FAQ

What is Rosuvastatin Calcium (CAS: 147098-20-2)?

Rosuvastatin Calcium (CAS: 147098-20-2) is a calcium salt of rosuvastatin, a potent HMG-CoA reductase inhibitor used to lower cholesterol. Its chemical formula is C23H28CaN2O7S, and it appears as a white crystalline powder. It is highly soluble in water and has a molecular weight of 524.63 g/mol. Rosuvastatin Calcium is known for its efficacy in managing hyperlipidemia and reducing cardiovascular risk.

What are the main uses of Rosuvastatin Calcium (CAS: 147098-20-2)?

Rosuvastatin Calcium (CAS: 147098-20-2) is primarily used in pharmaceuticals to treat hyperlipidemia and cardiovascular diseases. It helps reduce low-density lipoprotein (LDL) cholesterol, triglycerides, and increase high-density lipoprotein (HDL) cholesterol. Additionally, it is utilized in research for studying lipid metabolism and in industrial settings for drug formulation and development.

Is Rosuvastatin Calcium (CAS: 147098-20-2) safe?

Rosuvastatin Calcium (CAS: 147098-20-2) is considered safe when used as directed, but it requires proper handling to avoid adverse effects. Potential side effects include myopathy, liver enzyme elevation, and gastrointestinal issues. Safety standards ensure it meets regulatory guidelines for pharmaceutical use. Protective measures such as gloves and safety goggles are recommended during handling to prevent skin or eye contact.

How should Rosuvastatin Calcium (CAS: 147098-20-2) be stored?

Rosuvastatin Calcium (CAS: 147098-20-2) should be stored in a cool, dry place away from moisture and light. Maintain storage temperature between 15-30°C (59-86°F) and ensure it is kept in a sealed, light-resistant container. Avoid exposure to heat and humidity to preserve stability and potency. Always check the expiration date and follow manufacturer guidelines for safe storage.