Alcaftadine | CAS No. 147084-10-4

Alcaftadine

Basic Information

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CAS Number

147084-10-4

Molecular Formula

C19H21N3O

Molecular Weight

307.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

167°C

SMILES

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CN1CCC(=C2C3=CC=CC=C3CCN4C2=NC=C4C=O)CC1

InChI

InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3

InChIKey

MWTBKTRZPHJQLH-UHFFFAOYSA-N

LogP

2.7792000000000012

Topological Polar Surface Area

38.13 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

479

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

alcaftadina
Lastacaft
AS-56303
Alcaftadine, >=98% (HPLC)
NS00070524
SCHEMBL1602418
Lastacaft (TN)
R89674
4-(1-METHYL-PIPERIDIN-4-YLIDENE)-9,10-DIHYDRO-4H-3,10A-DIAZA-BENZO(F)AZULENE-1-CARBALDEHYDE
1794775-80-6
HMS3885B12
D06552
11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine-3-carbaldehyde
R-89674
NCGC00390732-04
BCP9000269
2-(1-Methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0(3,7)]tetradeca- 1(14),3,5,10,12-pentaene-6-carbaldehyde
11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde
CHEMBL1201747
AKOS025402002
147084-10-4
HY-17039
11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde
2-(1-methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0,3,7]tetradeca-1(10),3,5,11,13-pentaene-6-carbaldehyde
alcaftadinum
5H-Imidazo[2,1-b][3]benzazepine-3-carboxaldehyde,6,11-dihydro-11-(1-methyl-4-piperidinylidene)-
s4625
ALCAFTADINE [ORANGE BOOK]
FT-0661472
DB06766
ALCAFTADINE [INN]

MDL Number

MFCD09954106

FAQ

What are the physical and chemical properties of Alcaftadine (CAS: 147084-10-4)?

Alcaftadine (CAS: 147084-10-4) is a crystalline compound with a molecular weight of approximately 416.57 g/mol. It has a high solubility in water but is practically insoluble in organic solvents. Chemically, it is stable under normal conditions, but sensitive to light and heat, requiring storage under appropriate conditions to maintain its integrity.

How is Alcaftadine (CAS: 147084-10-4) typically synthesized?

Alcaftadine (CAS: 147084-10-4) is synthesized through a multi-step process involving condensation reactions, followed by esterification and cyclization. The key catalysts include titanium(IV) isopropoxide and anhydrous sodium carbonate. The process yields a high purity product with excellent selectivity, making it suitable for pharmaceutical applications.

What industries use Alcaftadine (CAS: 147084-10-4)?

Alcaftadine (CAS: 147084-10-4) is primarily used in the pharmaceutical industry for the treatment of allergic conjunctivitis. It is also explored in sensor technology for its optical properties and potential use in semiconductor materials due to its unique molecular structure.

What precautions should be taken when handling Alcaftadine (CAS: 147084-10-4)?

When handling Alcaftadine (CAS: 147084-10-4), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be ventilated. Emergency shower and eyewash stations should be readily available. Always refer to the Safety Data Sheet (SDS) for detailed information and guidelines.