5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine

Basic Information

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CAS Number

146954-74-7

Molecular Formula

C30H29FN2O7

Molecular Weight

548.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=CC(=O)NC5=O)F)O

InChI

InChI=1S/C30H29FN2O7/c1-37-22-12-8-20(9-13-22)30(19-6-4-3-5-7-19,21-10-14-23(38-2)15-11-21)39-18-24-27(35)26(31)28(40-24)33-17-16-25(34)32-29(33)36/h3-17,24,26-28,35H,18H2,1-2H3,(H,32,34,36)/t24-,26-,27-,28-/m1/s1

InChIKey

CSSFZSSZXOCCJB-YULOIDQLSA-N

LogP

3.158900000000001

Topological Polar Surface Area

112.01000000000002 Å²

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

873

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

对热敏感

Synonyms & References

English

1-[(2R,3R,4R,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-fluoro-4-hydroxyoxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
CS-W009378
AKOS005444204
MFCD06657648
AC-32230
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluorouridine
5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine
1-[(2R,3R,4R,5R)-5-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-3-FLUORO-4-HYDROXYOXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE
DTXSID40427732
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-
1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
2'-Deoxy-5'-O-DMT-2'-fluorouridine
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-uridine
5'-O-DMT-2'-fluoro-2'-deoxy-D-uridine
HG1172
5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine
1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
C30H29FN2O7
2'-Deoxy-5'-O-DMT-2'-fluoro-D-uridine
5'-O-DMT-2'-FLUORO-2'-DEOXYURIDINE
SCHEMBL4582323
CSSFZSSZXOCCJB-YULOIDQLSA-N
2'-Deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-fluorouridine
AS-72349
146954-74-7
HY-W008662
W-201302
2'-Fluoro-5'-O-DMT-uridine
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine
DMT-2'-F-dU
1-((2R,3R,4R,5R)

MDL Number

MFCD06657648

FAQ

What are the physical and chemical properties of 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine (CAS: 146954-74-7)?

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine is a crystalline compound with a molecular weight of approximately 678.5 g/mol. It is slightly soluble in water and has limited solubility in organic solvents. The compound exhibits low reactivity under normal conditions, but it can be susceptible to hydrolysis under acidic or basic conditions. It is stable at room temperature but should be stored in a dry, dark place to prevent degradation.

How is 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine (CAS: 146954-74-7) typically synthesized?

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine is synthesized through a multi-step process involving the protection of the hydroxyl group, followed by the introduction of the fluorine atom at the 2'-position, and finally the installation of the bis(4-methoxyphenyl)(phenyl)methyl group. The synthesis typically requires the use of protecting groups and mild oxidants. The yield of the final product is around 60-70%, and the reaction is carried out under anhydrous conditions to ensure high selectivity.

What industries use 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine (CAS: 146954-74-7)?

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine is primarily used in the pharmaceutical industry for the development of antiviral drugs. It is also explored for its potential applications in the synthesis of nucleoside analogs for cancer therapy. Additionally, due to its structural complexity, it may be used in research and development for the synthesis of new materials in the polymer and semiconductor industries.

What precautions should be taken when handling 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine (CAS: 146954-74-7)?

When handling 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine, it is crucial to use personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. The compound should be stored in a fume hood to minimize inhalation risks. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.