Compound Q&A
How is 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine (CAS: 146954-74-7) typically synthesized?
Answer
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5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine is synthesized through a multi-step process involving the protection of the hydroxyl group, followed by the introduction of the fluorine atom at the 2'-position, and finally the installation of the bis(4-methoxyphenyl)(phenyl)methyl group. The synthesis typically requires the use of protecting groups and mild oxidants. The yield of the final product is around 60-70%, and the reaction is carried out under anhydrous conditions to ensure high selectivity.
About
CAS No
146954-74-7
English Name
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine
Molecular Formula
C30H29FN2O7
Molecular Weight
548.57 g/mol
SMILES
COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=CC(=O)NC5=O)F)O
InChIKey
CSSFZSSZXOCCJB-YULOIDQLSA-N
Last Updated: 2025-10-16 16:48
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