Terlipressin | CAS No. 14636-12-5

Terlipressin

Basic Information

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CAS Number

14636-12-5

Molecular Formula

C52H74N16O15S2

Molecular Weight

1227.4 g/mol

EINECS

238-680-8

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

White

Melting Point

>170°C (dec.)

Boiling Point

1824.0±65.0 °C(Predicted)

Density

1.46±0.1 g/cm3(Predicted)

Flash Point

1056.9±34.3 °C

Solubility

DMSO (Slightly), Methanol (Slightly)

Refractive Index

1.664

SMILES

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C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)NC(=O)CNC(=O)CNC(=O)CN)C(=O)NC(CCCCN)C(=O)NCC(=O)N

InChI

InChI=1S/C52H74N16O15S2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42(73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37/h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,65,81)(H,66,77)(H,67,80)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1

InChIKey

BENFXAYNYRLAIU-QSVFAHTRSA-N

LogP

-6.980500000000003

pKa

9.90±0.15(Predicted)

Topological Polar Surface Area

512.8499999999998 Å²

Hydrogen Bond Donor/Acceptor

21 / 31

Complexity

2380

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Terlipressinum (INN-Latin)
DTXSID7048952
Terlipressina
Terlipressinum
TERLIPRESSIN (MART.)
NS00024791
VASOPRESSIN, N-(GLYCYLGLYCYLGLYCYL)-8-L-LYSINE-
Terlivaz
DTXCID0028878
glycyl-glycyl-glycyl-L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-lysyl-glycinamide (4->9)-disulfide
Terlipressina [INN-Spanish]
N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
glypressin
GLY-GLY-GLY-CYS-TYR-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2 (4-9 DISULFIDE)
AKOS015994637
Terlipressin (USAN/INN)
J-008213
DB02638
Tox21_113374
Terlipressine [INN-French]
C72780
GLYCYLGLYCYLGLYCYL(8-L-LYSINE)VASOPRESSIN
Q324147
CHEBI:135905
Terlipressin [USAN:INN:BAN]
EX-A3116
HY-12554
N-(N-(N-glycylglycyl)glycyl)-L-lysinevasopressin
Terlipresina
EINECS 238-680-8
GTPL11241

MDL Number

MFCD00155450

EC Number

238-680-8

Customs Code

3504009000

FAQ

What is Terlipressin (CAS: 14636-12-5)?

Terlipressin is a synthetic vasoactive drug with the chemical formula C17H25NO4S. It is a non-peptide vasopressin receptor agonist, primarily used for its potent vasoconstrictive and natriuretic properties. Terlipressin is known for its ability to increase blood pressure and reduce fluid volume, making it effective in certain medical conditions.

What are the main uses of Terlipressin (CAS: 14636-12-5)?

Terlipressin is mainly used in the treatment of hepatorenal syndrome and as a vasopressor in cases of severe hypotension. It is also applied in research for studying cardiovascular and renal functions, and in veterinary medicine for managing specific conditions in animals.

Is Terlipressin (CAS: 14636-12-5) safe?

Terlipressin is generally considered safe when used as directed, but it may cause side effects such as hypertension, bradycardia, and electrolyte imbalances. Proper handling and adherence to safety guidelines are essential, especially in medical and research settings. It is classified as a prescription drug and should be used under professional supervision.

How should Terlipressin (CAS: 14636-12-5) be stored?

Terlipressin should be stored in a tightly sealed container, protected from light and moisture, at a controlled room temperature (15-30°C). It is important to maintain proper storage conditions to ensure stability and potency of the compound.