3-Amino-2-pyridinecarboxylic acid

Basic Information

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CAS Number

1462-86-8

Molecular Formula

C6H6N2O2

Molecular Weight

138.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Yellow to Brown Solid

Melting Point

211-217°C

Boiling Point

386.6℃ at 760 mmHg

Density

1.417

Flash Point

187.6℃

Solubility

Soluble in acetone, ethanol and methanol.

SMILES

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C1=CC(=C(N=C1)C(=O)O)N

InChI

InChI=1S/C6H6N2O2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,7H2,(H,9,10)

InChIKey

BOOMHTFCWOJWFO-UHFFFAOYSA-N

LogP

0.3620000000000001

Topological Polar Surface Area

76.21 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

138

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

W-205636
CL0127
3-Amino-pyridine-2-carboxylic acid;3-Amino-2-pyridinecarboxylic acid
3-Amino-2-pyridinecarboxylic acid
3-Aminopicolinic acid
Z1201619040
CHEMBL3617319
SY005540
UNII-KRX7SG6NCS
3-amino-2-pyridine carboxylic acid
NS00024782
BRN 0003600
3-Amino-pyridine-2-carboxylic acid
DTXSID00163301
MFCD00090153
CS-W002358
3-Amino-2-pyridinecarboxylicacid
3-Amino-2-carboxypyridine
3-Aminopicolinicacid
3-Amino-2-pyridinecarboxylic acid #
EINECS 215-971-8
3-aminopyridin-2-carboxylic acid
3-Amino-2-pyridinecarboxylic acid, AldrichCPR
3-Amino-2-picolinic acid
STR06701
1462-86-8
PS-4525
PB32134
SCHEMBL128343
AM20050819
FT-0615058

MDL Number

MFCD00090153

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Amino-2-pyridinecarboxylic acid (CAS: 1462-86-8)?

3-Amino-2-pyridinecarboxylic acid is a crystalline compound with a molecular weight of approximately 177.18 g/mol. It has a pKa of around 6.8 and is soluble in water and organic solvents such as ethanol and methanol. This compound is known for its reactivity in nucleophilic substitution reactions and condensation reactions.

How is 3-Amino-2-pyridinecarboxylic acid (CAS: 1462-86-8) typically synthesized?

3-Amino-2-pyridinecarboxylic acid is commonly synthesized via the reduction of 2-pyridinecarboxaldehyde with hydrogen gas in the presence of a catalyst like palladium on carbon, followed by the addition of ammonia. The process provides good yield and selectivity, making it a reliable method for industrial production.

What industries use 3-Amino-2-pyridinecarboxylic acid (CAS: 1462-86-8)?

3-Amino-2-pyridinecarboxylic acid is widely used in the pharmaceutical industry for the synthesis of various drugs due to its aromatic and amine functionalities. It also finds applications in the polymer industry for modifying properties of polymers and in the development of sensors and semiconductors.

What precautions should be taken when handling 3-Amino-2-pyridinecarboxylic acid (CAS: 1462-86-8)?

When handling 3-Amino-2-pyridinecarboxylic acid, appropriate personal protective equipment (PPE) such as gloves and safety goggles should be worn. This compound should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of spill, it should be handled with a fume hood and appropriate spill cleanup kits. Always refer to the Safety Data Sheet (SDS) for detailed safety information.