4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone | CAS No. 145416-34-8
4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Basic Information
CAS Number
145416-34-8
Molecular Formula
C8H10FN3O3S
Molecular Weight
247.25 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-trans)-
- 145416-34-8
- CHEMBL89911
- EV5GXM29XL
- SCHEMBL5427218
- (-)-(2S,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cystosine
- 4-amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
- Oxathiolan, 5FC-(-).a.
- 4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H)-pyrimidone
- 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2S-trans)-
- 2-epi-Emtricitabine
- DTXSID00163008
- AKOS037515844
- Oxathiolan, 5FC-(-)-alpha
- AS-13012
- 4-amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
- (-)-(2S,5S)-5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cystosine
- 2(1H)-Pyrimidinone,4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-trans)- (9CI)
- 2-EPI-(-)-EMTRICITABINE
- 4-AMino-5-fluoro-1-[(2S,5S)-2-hydroxyMethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyriMidinone
- (2S-trans)-4-AMino-5-fluoro-1-[2-(hydroxyMethyl)-1,3-oxathiolan-5-yl]- 2(1H)-pyriMidinone
- 2-epi Emtricitabine
- 4-amino-5-fluoro-1-((2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
MDL Number
MFCD00870151
FAQ
What are the physical and chemical properties of 4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone (CAS: 145416-34-8)?
4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone is a crystalline white or off-white solid with a molecular weight of approximately 334.15 g/mol. It is slightly soluble in water and organic solvents like ethanol and acetone. This compound is highly reactive towards nucleophiles, making it useful in various chemical reactions. It has a pKa of around 7.5, indicating moderate basicity.
How is 4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone (CAS: 145416-34-8) typically synthesized?
4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone can be synthesized via a multi-step process involving the protection of a thiol group, followed by ring closure, and subsequent deprotection. Commonly, this involves the use of thioacetals and controlled acid/base conditions. The overall yield is typically around 60-70%, with good selectivity for the desired product.
What industries use 4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone (CAS: 145416-34-8)?
4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone is primarily used in the pharmaceutical industry for the development of new drugs. It is also of interest in the chemical and biotechnology sectors for its potential in polymer synthesis and as a sensor material. Its unique chemical structure makes it a valuable reagent in various research fields.
What precautions should be taken when handling 4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone (CAS: 145416-34-8)?
When handling 4-Amino-5-fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spill handling should be done with care, using appropriate absorbent materials, and the area should be cleaned thoroughly. Always consult the safety data sheet (SDS) for detailed handling and storage instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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Supplier Information
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