2-Pyridinecarboxamide

Basic Information

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CAS Number

1452-77-3

Molecular Formula

C6H6N2O

Molecular Weight

122.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

105.0 to 109.0 deg-C

Boiling Point

143°C/20mmHg

Flash Point

156.0±20.4 °C

Refractive Index

1.5350 (estimate)

Vapor Pressure

0.0±0.7 mmHg at 25°C

SMILES

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NC(=O)c1ccccn1

InChI

InChI=1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)

InChIKey

IBBMAWULFFBRKK-UHFFFAOYSA-N

LogP

0.18049999999999994

Topological Polar Surface Area

55.980000000000004 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

114

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

Picolinamide
2-Picolinamide
Pyridine-2-carboxamide,(2-Picolinamide)
Pyridine-2-carboxamide
2-Pyridine-carboxamide
α-Picolinamide
2-Carbamoylpyridine
NSC 524473
Picolinic acid amide
Picolinoylamide
alpha-(Aminocarbonyl)pyridine
alpha-Picolinamide
TIMTEC-BB SBB008128
2-PYRIDINECARBOXAMIDE
PicolinaMide 98%
Picolinamide ,98%
2-aminocarbonyl-pyridine
Pyridinecarboxamide
Picolinamide, 98%
.alpha.-Picolinic acid amide
IBBMAWULFFBRKK-UHFFFAOYSA-N
I3550CCL59
picolamide
pyridine amide
2-picoloylamine
pyridine carboxamide
.alpha.-Picolinamide
pyridine 2-carboxamide
2-picolinic acid amide
.alpha.-Pyridinecarboxa
picolinamide

MDL Number

MFCD00151999

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Pyridinecarboxamide (CAS: 1452-77-3)?

2-Pyridinecarboxamide is a white crystalline solid with a molecular weight of 119.12 g/mol. It is slightly soluble in water but has good solubility in organic solvents like ethanol and acetone. Its chemical properties include basicity and nucleophilicity, making it reactive in condensation and amidation reactions.

How is 2-Pyridinecarboxamide (CAS: 1452-77-3) typically synthesized?

2-Pyridinecarboxamide can be synthesized via several methods, including the amidation of 2-pyridinecarboxaldehyde with ammonia or an amine. Another method involves the reaction of a pyridine derivative with carbon dioxide in the presence of an appropriate base.

What industries use 2-Pyridinecarboxamide (CAS: 1452-77-3)?

2-Pyridinecarboxamide finds applications in the pharmaceutical industry for the synthesis of certain drugs and in the polymer industry for the production of functionalized polymers. It is also used in the development of sensors and in the semiconductor industry as a precursor in the chemical vapor deposition process.

What precautions should be taken when handling 2-Pyridinecarboxamide (CAS: 1452-77-3)?

When handling 2-Pyridinecarboxamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be properly decontaminated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.