2-Bromo-3,5-dichloropyridine

Basic Information

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CAS Number

14482-51-0

Molecular Formula

C5H2BrCl2N

Molecular Weight

226.89 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

41.0 to 45.0 deg-C

Boiling Point

243.3°C at 760 mmHg

Density

1.848

Flash Point

101℃

Refractive Index

1.508

SMILES

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C1=C(C=NC(=C1Cl)Br)Cl

InChI

InChI=1S/C5H2BrCl2N/c6-5-4(8)1-3(7)2-9-5/h1-2H

InChIKey

QCKPJWDIDCGQRB-UHFFFAOYSA-N

LogP

3.150900000000001

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

101

Safety Information

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GHS Hazard Pictograms

H315

H319

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

AB05062
AC-9472
FT-0637089
SCHEMBL544483
AM20070043
CS-W007790
EN300-142157
Q-101222
MFCD00233990
AKOS000267456
RB1046
GS-6730
DTXSID90355733
14482-51-0
2-Bromo-3,5-dichloropyridine, AldrichCPR
2-bromo-3,5-dichloropyridin
2-Bromo-3,5-dichloropyridine
Pyridine, 2-bromo-3,5-dichloro-
2-Bromo-3,5-dichloro-pyridine
QCKPJWDIDCGQRB-UHFFFAOYSA-N
3,5-Dichloro-2-Bromopyridine
SY012471
BCP22111
A3142
B3734
2-Bromo-3,5 Dichloro Pyridine
3,5-Dichloro-2-bromopyridine
2-Brom-3,5-dichlor-pyridin
2-bromo-3,5-dichloro-pyridine
5-Dichloro-2-broMopyridine
2-BROMO-3,5-DICHLOROPYRIDUNE

MDL Number

MFCD00233990

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Bromo-3,5-dichloropyridine (CAS: 14482-51-0)?

2-Bromo-3,5-dichloropyridine is a crystalline solid with a molecular weight of approximately 257.01 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong bases to form less stable derivatives. It exhibits high reactivity towards nucleophiles and can undergo substitution reactions. Its high reactivity and low solubility in water make it challenging to handle and manipulate in solution.

How is 2-Bromo-3,5-dichloropyridine (CAS: 14482-51-0) typically synthesized?

2-Bromo-3,5-dichloropyridine is typically synthesized via a two-step process. First, 3,5-dichloropyridine is brominated using bromine in the presence of a Lewis acid like aluminum trichloride to generate the brominated product. The second step involves the brominated compound undergoing another substitution reaction with a halogen or another electrophile under appropriate conditions to complete the synthesis. The process yields a product with high purity, though care must be taken to avoid unwanted side reactions.

What industries use 2-Bromo-3,5-dichloropyridine (CAS: 14482-51-0)?

2-Bromo-3,5-dichloropyridine is used primarily in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the modification of polymer properties. Additionally, it has applications in sensor technology and semiconductor manufacturing, where its unique chemical properties are leveraged for specific functional requirements.

What precautions should be taken when handling 2-Bromo-3,5-dichloropyridine (CAS: 14482-51-0)?

When handling 2-Bromo-3,5-dichloropyridine, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to protect against skin and eye contact. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. In case of a spill, immediately clean up using appropriate absorbent materials and dispose of the waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.