Risperidone EP Impurity C (9-Hydroxy Risperidone, Paliperidone)

Basic Information

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CAS Number

144598-75-4

Molecular Formula

C23H27FN4O3

Molecular Weight

426.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

No data avaiable

Melting Point

181-186°C

Boiling Point

612.3°C at 760 mmHg

Density

No data available

Flash Point

9℃

Solubility

DMSO: soluble2mg/mL, clear (warmed)

Refractive Index

1.692

Vapor Pressure

No data available

SMILES

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CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F

InChI

InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

InChIKey

PMXMIIMHBWHSKN-UHFFFAOYSA-N

LogP

3.0813200000000016

Topological Polar Surface Area

84.39 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

764

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, 9-Hydroxyrisperidone
HY-A0019
Paliperidone- Bio-X
3-[2-[4-(6-Fluoro-1,2-benzisoxazol- 3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hy droxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
NSC 759623
3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
SMR001456280
144598-75-4 (free base)
4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8-tetrahydro-9-hydroxy-2-methyl-
NCGC00261247-01
FT-0670101
PALIPERIDONE [USAN]
paliperidonum
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
(R)-9-Hydroxy Risperidone
Risperidone impurity, 9-hydroxyrisperidone-
FT-0600425
9-Hydroxyrisperidone, 1mg/ml in Methanol
BCPP000132
9-OH-risperidone
R-76477
N05AX13
3-[ 2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
9-Hydroxyrisperidone
BCP02338
RISPERIDONE IMPURITY, 9-HYDROXYRISPERIDONE-(USP IMPURITY)
rac-paliperidone
BP164223
C23H27FN4O3
LP00562

MDL Number

MFCD00871802

FAQ

What is Risperidone EP Impurity C (CAS: 144598-75-4)?

Risperidone EP Impurity C, also known as 9-Hydroxy Risperidone or Paliperidone, is a metabolite of the antipsychotic drug risperidone. It has the chemical formula C18H22FN3O2 and is a white to pale yellow crystalline solid. This compound is commonly found in pharmaceutical impurity testing and is used to ensure the purity and safety of risperidone-based medications.

What are the main uses of Risperidone EP Impurity C (CAS: 144598-75-4)?

Risperidone EP Impurity C is primarily used in pharmaceutical quality control to detect and quantify impurities in risperidone formulations. It also serves as a reference standard in drug development, research, and analytical testing. Additionally, it is relevant in understanding drug metabolism and ensuring compliance with regulatory standards in the pharmaceutical industry.

Is Risperidone EP Impurity C (CAS: 144598-75-4) safe?

Risperidone EP Impurity C is generally considered safe when handled according to standard laboratory procedures. However, as with any chemical, it should be treated with care, using appropriate personal protective equipment (PPE). Safety data sheets (SDS) recommend avoiding inhalation, ingestion, and skin contact, and proper disposal is necessary to comply with environmental and safety regulations.

How should Risperidone EP Impurity C (CAS: 144598-75-4) be stored?

Risperidone EP Impurity C should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is recommended to keep it in a sealed container to prevent moisture and contamination. Avoid exposure to light and maintain controlled humidity levels to ensure stability and prolong shelf life.