(1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid | CAS No. 144-80-9

Q: What is (1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid (CAS: 144-80-9)?

This compound is a sulfonamide derivative with the chemical formula C9H10N2O3S. It is characterized by its amide and sulfonyl functional groups, and it exhibits specific physical properties such as solubility in polar solvents. The compound is commonly used in chemical synthesis and research due to its reactivity and structural versatility.

Q: What are the main uses of (1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid (CAS: 144-80-9)?

It is primarily used in pharmaceutical research as an intermediate for drug development, particularly in the synthesis of compounds with antimicrobial or anti-inflammatory properties. It also finds applications in organic chemistry for the preparation of other functionalized molecules and in industrial processes where sulfonamide derivatives are required.

Q: Is (1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid (CAS: 144-80-9) safe?

Safety precautions should be taken when handling this compound, as it may cause skin and eye irritation. It is advisable to use appropriate personal protective equipment (PPE) such as gloves and goggles. While it is generally considered safe in controlled environments, long-term exposure or ingestion should be avoided to ensure safety in chemical handling and research.

Q: How should (1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid (CAS: 144-80-9) be stored?

This compound should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is recommended to keep it in a sealed container to prevent moisture absorption and contamination. Avoid exposure to air and light to maintain its chemical stability and prolong shelf life.

(1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid

Basic Information

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CAS Number

144-80-9

Molecular Formula

C8H10N2O3S

Molecular Weight

214.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

179.0 to 184.0 deg-C

Boiling Point

239.433°C at 760 mmHg

Water Solubility

<0.01 g/100 mL at 16 ºC

Solubility

ethanol: soluble50mg/mL

Refractive Index

1.5690 (estimate)

SMILES

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CC(=O)NS(=O)(=O)C1=CC=C(C=C1)N

InChI

InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)

InChIKey

SKIVFJLNDNKQPD-UHFFFAOYSA-N

LogP

0.0935999999999998

Topological Polar Surface Area

89.26 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

299

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, strong acids.

Toxicity

LD50 orally in dogs: 8000 mg/kg (Fisher)

Synonyms & References

English

SULFACETAMIDE [ORANGE BOOK]
Sulfacet
NCGC00018242-04
N-Sulphanilylacetamide
KBio3_001993
N(sup 1)-Acetyl-4-aminophenylsulfonamide
Prestwick1_000014
NCGC00021857-04
UNII-4965G3J0F5
DTXCID406060
SULFACETAMIDE (MART.)
SMR000058173
SBI-0051519.P003
Sulfacetamide, VETRANAL(TM), analytical standard
MLS001076499
BPBio1_000053
AC-7630
SULSTER
NCGC00018242-08
N-Acetylsulfanilamine
NCGC00018242-02
N(1)-acetylsulfanilamide
Bleph-10 liquifilm
Sulfacetamide, United States Pharmacopeia (USP) Reference Standard
Albucid
HMS1921A11
HMS3259G06
SPBio_001968
NSC757323
N-(p-Aminobenzenesulfonyl)acetamide
Solfacetamide [DCIT]

MDL Number

MFCD00066501

Customs Code

2935009090

FAQ

What is (1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid (CAS: 144-80-9)?

This compound is a sulfonamide derivative with the chemical formula C9H10N2O3S. It is characterized by its amide and sulfonyl functional groups, and it exhibits specific physical properties such as solubility in polar solvents. The compound is commonly used in chemical synthesis and research due to its reactivity and structural versatility.

What are the main uses of (1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid (CAS: 144-80-9)?

It is primarily used in pharmaceutical research as an intermediate for drug development, particularly in the synthesis of compounds with antimicrobial or anti-inflammatory properties. It also finds applications in organic chemistry for the preparation of other functionalized molecules and in industrial processes where sulfonamide derivatives are required.

Is (1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid (CAS: 144-80-9) safe?

Safety precautions should be taken when handling this compound, as it may cause skin and eye irritation. It is advisable to use appropriate personal protective equipment (PPE) such as gloves and goggles. While it is generally considered safe in controlled environments, long-term exposure or ingestion should be avoided to ensure safety in chemical handling and research.

How should (1Z)-N-[(4-Aminophenyl)sulfonyl]ethanimidic acid (CAS: 144-80-9) be stored?

This compound should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is recommended to keep it in a sealed container to prevent moisture absorption and contamination. Avoid exposure to air and light to maintain its chemical stability and prolong shelf life.