1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol | CAS No. 144-11-6
1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol
Basic Information
CAS Number
144-11-6
Molecular Formula
C20H31NO
Molecular Weight
301.47 g/mol
AD
Basic Physical Properties
Melting Point
258.5 ºC
Boiling Point
442.59°C (rough estimate)
Refractive Index
1.5614 (estimate)
Synonyms & References
English
- Trihexylphenizyl
- Trihexyphenidyle (INN-French)
- 1-Piperidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-
- NCGC00016003-15
- (+/-)-Triphenidyl; Benzhexol; NSC 12268
- Q2991856
- Trihexifenidilo
- Benzhexol free base
- 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-,
- NS00006523
- CCG-205200
- NSC_5572
- .alpha.-Cyclohexyl-.alpha.-phenyl-1-piperidinepropanol
- Trihexyphenidyle [INN-French]
- IDI1_000372
- Spectrum5_001465
- KBio2_003680
- Trihexyphenidyl (INN)
- 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol #
- SPBio_000757
- AB00053559
- AKOS015914081
- trihexyphenidyl
- TRIHEXYPHENIDYL [INN]
- BSPBio_002930
- NSC-12268
- SPBio_002802
- 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-
- NSC 12268
- 144-11-6
- Trihexyphenidyle
MDL Number
MFCD00599600
Customs Code
2933399090
FAQ
What are the physical and chemical properties of 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol (CAS: 144-11-6)?
1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol is a colorless to light yellow liquid with a molecular weight of approximately 312.37 g/mol. It has a melting point of -18°C and a boiling point of 220°C. The compound is slightly soluble in water but miscible with common organic solvents. It exhibits basic properties due to the piperidine group and is known for its reactivity towards electrophiles.
How is 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol (CAS: 144-11-6) typically synthesized?
1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol is typically synthesized via a multistep process involving condensation reactions and alkylation. The key steps include the formation of a piperidine derivative and subsequent coupling with cyclohexyl and phenyl groups. The reaction involves the use of mild acid catalysts and careful control of reaction conditions to achieve a yield of up to 85%.
What industries use 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol (CAS: 144-11-6)?
1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol is primarily used in the pharmaceutical industry as a precursor for active pharmaceutical ingredients (APIs). It also finds application in the production of certain polymers and as a reagent in organic synthesis. Additionally, it can be used in the development of sensors and as a component in some semiconductor manufacturing processes.
What precautions should be taken when handling 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol (CAS: 144-11-6)?
When handling 1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Use a fume hood to minimize exposure to the vapor. Store the compound in a cool, dry place away from direct sunlight and ignition sources. In case of spill, avoid direct contact and clean up using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed safety information.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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