2-Methyl-2-propanyl (3R)-3-hydroxy-1-piperidinecarboxylate

Basic Information

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CAS Number

143900-43-0

Molecular Formula

C10H19NO3

Molecular Weight

201.27 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

43-50 °C

Boiling Point

292.3±33.0 °C at 760 mmHg

Density

1.107

Refractive Index

1.495

Specific Rotation

-19° - -25° (c=5, MeOH)

SMILES

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CC(C)(C)OC(=O)N1CCCC(C1)O

InChI

InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m1/s1

InChIKey

UIJXHKXIOCDSEB-MRVPVSSYSA-N

LogP

1.3781999999999999

Topological Polar Surface Area

49.769999999999996 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

210

Safety Information

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GHS Hazard Pictograms

H301

H315

H318

H335

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

(R)-(-)-N-tert-butoxycarbonyl-3-piperidinol
3-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester;(R)-1-N-BOC-3-HYDROXYPIPERIDINE
N-BOC-3(R)-hydroxy-piperidine
CS-W008719
(3R)-3-Hydroxypiperidine, N-Boc protected
(r)-n-boc-3-hydroxypiperidine
(R)-(+)-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester
Q-102972
(R)-3-Hydroxypiperidine-1-carboxylic acid tert-butyl ester
(3R)-1-t-butoxycarbonyl-3-hydroxypiperidine
(R)-3-hydroxypiperidine-1-carboxylic acid t-butyl ester
(r)-tert butyl-3-hydroxypiperidine-1-carboxylate
(3R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
tert-butyl (3r)-3-hydroxyhexahydro-1-pyridinecarboxylate
B4199
(R)-3-hydroxy-piperidine carboxylic acid tert-butyl ester
1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3R)-
HY-40022
(R)-1-N-Boc-3-hydroxypiperidine
AM742
(R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate
DTXSID60363880
BCP08552
tert-Butyl (3R)-3-hydroxy-1-piperidincarboxylate
UIJXHKXIOCDSEB-MRVPVSSYSA-N
(R)-1-Boc-3-hydroxypiperidine
143900-43-0
(R)-1-(tert-butoxycarbonyl)-3-hydroxypiperidine
MFCD04115306
(R)-1-Boc-3-hydroxypiperidine, 95%
AC-2185

MDL Number

MFCD04115306

FAQ

What regulatory guidelines apply to 2-Methyl-2-propanyl (3R)-3-hydroxy-1-piperidinecarboxylate (CAS: 143900-43-0)?

2-Methyl-2-propanyl (3R)-3-hydroxy-1-piperidinecarboxylate (CAS: 143900-43-0) is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) as a substance that may pose environmental hazards. In the European Union, it falls under REACH regulations, requiring manufacturers and importers to register substances above a certain tonnage. FDA and EPA may also regulate its use and disposal in the United States, particularly concerning environmental protection and worker safety.

Are there alternatives to 2-Methyl-2-propanyl (3R)-3-hydroxy-1-piperidinecarboxylate in synthesis?

For synthesizing similar compounds, alternative reagents such as 2-methyl-2-propanol and various carboxylic acids can be used. Isomers like (3S)-3-hydroxy-1-piperidinecarboxylic acid may also serve as viable substitutes. These alternatives can provide similar functionalities while potentially offering different reactivity profiles in the synthesis process.

What is the market or research trend for 2-Methyl-2-propanyl (3R)-3-hydroxy-1-piperidinecarboxylate (CAS: 143900-43-0)?

The market for 2-Methyl-2-propanyl (3R)-3-hydroxy-1-piperidinecarboxylate (CAS: 143900-43-0) is expected to grow due to its applications in pharmaceuticals and fine chemicals. Research trends indicate a focus on its use in drug development, particularly as a precursor for more complex molecules. Recent studies are also exploring its potential in polymer chemistry and cosmetics.

How should waste containing 2-Methyl-2-propanyl (3R)-3-hydroxy-1-piperidinecarboxylate (CAS: 143900-43-0) be handled?

Waste containing 2-Methyl-2-proanyl (3R)-3-hydroxy-1-piperidinecarboxylate (CAS: 143900-43-0) should be collected in appropriate containers and stored in a closed, well-ventilated area. Incineration or professional waste disposal services are recommended to ensure proper destruction or recycling. Environmental precautions include minimizing contamination and ensuring compliance with local and international waste disposal regulations to protect human health and the environment.