Hydroquinidine

Basic Information

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CAS Number

1435-55-8

Molecular Formula

C20H26N2O2

Molecular Weight

326.44 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Powder

Melting Point

169-170 °C

Boiling Point

498.4°C at 760 mmHg

Flash Point

255.2±24.6 °C

Solubility

chloroform: 0.1 g/mL, clear

Refractive Index

1.6800 (estimate)

Specific Rotation

226 º (c=2 in EtOH)

SMILES

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CCC1CN2CCC1C[C@@H]2C(O)c3ccnc4ccc(OC)cc34

InChI

InChI=1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13?,14?,19-,20?/m1/s1

InChIKey

LJOQGZACKSYWCH-LDOBDJHISA-N

LogP

3.3972000000000024

Topological Polar Surface Area

45.59 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

432

Safety Information

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GHS Hazard Pictograms

H302

H312

H332

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H332 Harmful if inhaled
Acute toxicity, inhalation

Hazard Class

Class 6.1(b) Class 6.1(b)

Synonyms & References

English

Hydroquinidine
Dihydroquinine
(8a,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol
(5-Ethyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol
hydroquinidine anhydrous
(+)-Dihydroquinidine
Dihydroquinidine
(+)-Hydroquinidine
(9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
Hydroconquinine
(9S)-10,11-Dihydro-6′-methoxycinchonan-9-ol
Hydroqninidine
Hydroconchinine
Hydroxyquinidine
2-Hydroquinidine
aluminum triacetate
10,11-Dihydroquinidine
8P68XPY4HG
Dihydrochinidin
HYDROQUININE
(1S)-((2R,4S,5R)-5-Ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol
LCN 834
AK164414
Hydroquinidine, 95%
HYDROQUINIDINE
DIHYDROQUINIDINE
(S)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol

MDL Number

MFCD29907227

Customs Code

2933990090

FAQ

What is Hydroquinidine (CAS: 1435-55-8)?

Hydroquinidine is a quinidine derivative used primarily in pharmaceutical applications. Its chemical formula is C19H22N2O2, and it is a white crystalline powder with a bitter taste. Hydroquinidine is known for its anticholinergic properties and is commonly used as an antimalarial agent. It is also a precursor in the synthesis of other pharmaceutical compounds.

What are the main uses of Hydroquinidine (CAS: 1435-55-8)?

Hydroquinidine is mainly used in the treatment of malaria, particularly in combination with other antimalarial drugs. It also serves as an anticholinergic in medical treatments and has applications in the synthesis of pharmaceutical intermediates. Additionally, it is used in research settings for drug development and chemical studies related to antimalarial and cardiovascular agents.

Is Hydroquinidine (CAS: 1435-55-8) safe?

Hydroquinidine is generally considered safe when used as directed, but it requires careful handling due to potential toxicity. It may cause side effects such as dizziness, nausea, and cardiac issues. Safety standards recommend following proper protective measures, including wearing gloves and goggles, to minimize exposure. It is not for use in food or cosmetics and should be handled in accordance with chemical safety guidelines.

How should Hydroquinidine (CAS: 1435-55-8) be stored?

Hydroquinidine should be stored in a cool, dry place away from light. It is typically kept in a sealed container at a temperature below 25°C and humidity levels below 60%. Proper storage is essential to maintain its chemical stability and prevent degradation. Avoid exposure to moisture, heat, and direct sunlight to ensure long-term preservation.