1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride (1:1) | CAS No. 1429757-68-5

1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride (1:1)

Basic Information

CAS Number

1429757-68-5

Molecular Formula

C23H22Cl3FN4O3

Molecular Weight

527.81 g/mol

AD

Basic Physical Properties

Cl.COC1=CC2=NC=NC(NC3C=CC(Cl)=C(Cl)C=3F)=C2C=C1OC1CCN(CC1)C(=O)C=C

InChI

InChI=1S/C23H21Cl2FN4O3.ClH/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26;/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29);1H

InChIKey

OMYSOLOMWJFVNK-UHFFFAOYSA-N

LogP

5.805500000000005

Topological Polar Surface Area

76.58000000000001 Ų

Hydrogen Bond Donor/Acceptor

1 / 7

Synonyms & References

English

  • HM 781-36B
  • Poziotinib hydrochloride

FAQ

What is 1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride (CAS: 1429757-68-5)?

1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride is a quinazoline derivative with potential pharmaceutical applications. It contains a quinazoline ring, a piperidine group, and a propenone moiety, which contribute to its chemical properties and biological activities.

What are the main uses of 1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride (CAS: 1429757-68-5)?

1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride is primarily used in the development of potential anti-inflammatory and antiviral drugs. It may also have applications in cancer research and therapy.

Is 1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride (CAS: 1429757-68-5) safe?

1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride is generally safe when handled with proper precautions. Users should avoid contact with skin and eyes, and ensure proper ventilation during use. It is advisable to follow safety guidelines and consult a safety data sheet (SDS) for detailed information.

How should 1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride (CAS: 1429757-68-5) be stored?

1-[4-({4-[(3,4-Dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-2-propen-1-one hydrochloride should be stored in a cool, dry place, away from direct sunlight and heat sources. It should be kept in a tightly sealed container and away from moisture. Ideally, store it at room temperature (15-30°C) and protect from light to maintain its stability and effectiveness.

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