Xipamide | CAS No. 14293-44-8

Xipamide

Basic Information

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CAS Number

14293-44-8

Molecular Formula

C15H15ClN2O4S

Molecular Weight

354.82 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

255-256 ºC

Solubility

DMSO: soluble20mg/mL, clear

Refractive Index

1.6100 (estimate)

SMILES

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CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N

InChI

InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)

InChIKey

MTZBBNMLMNBNJL-UHFFFAOYSA-N

LogP

2.5621400000000008

Topological Polar Surface Area

109.49 Å²

Hydrogen Bond Donor/Acceptor

4 / 6

Complexity

526

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

D06341
Benzamide, 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-
5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide
CAS-14293-44-8
4-Chloro-N-(2 pound not6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide
4-Chlor-5-sulfamoyl-2',6'-salicyloxylidid [German]
4-Chloro-5-sulfamoyl-2?,6?-salicyloxylidide
MJF 10,938
DS-1401
Diurex (lacer)
CS-W023041
DTXSID5023744
Benzamide,5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-
DTXCID503744
XIPAMIDE [INN]
Aquaphor (diuretic)
2',6'-Salicyloxylidide, 4-chloro-5-sulfamoyl-
CHEBI:135499
NS00008537
A807988
Aquaphor(tm), original formula ointment base
Q600951
Chronexan
Xipamide (USAN)
MFCD00865927
HY-W042301
s5076
BE-1293
Xipamidum
AC-911
C15H15ClN2O4S

MDL Number

MFCD00865927

Customs Code

2935009090

FAQ

What regulatory guidelines apply to Xipamide (CAS: 14293-44-8)?

Xipamide (CAS: 14293-44-8) is classified under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) as a skin irritant. It falls under the European Chemicals Agency (ECHA) regulations for the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH). Additionally, the Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) have specific requirements for its use in pharmaceuticals and environmental safety, respectively. Compliance with these regulations is essential for safe handling and use.

Are there alternatives to Xipamide (CAS: 14293-44-8) in synthesis?

Alternatives to Xipamide (CAS: 14293-44-8) in synthesis include other diuretics such as furosemide or bumetanide. These alternatives are often used in pharmaceutical applications due to their similar diuretic properties. Additionally, researchers may explore new synthetic routes using isomers or analogs of Xipamide to improve efficacy or reduce side effects.

What is the market or research trend for Xipamide (CAS: 14293-44-8)?

The market for Xipamide (CAS: 14293-44-8) is stable, with ongoing research focusing on its use in treating hypertension and heart failure. Recent trends include studies on its potential in combination therapies and its long-term side effects. Market trends also reflect a shift towards more effective and less toxic diuretics, driving innovation in this field.

How should waste containing Xipamide (CAS: 14293-44-8) be handled?

Waste containing Xipamide (CAS: 14293-44-8) should be collected in appropriate containers and stored separately to prevent contamination. Proper incineration or professional waste disposal is recommended. Environmental protection measures include ensuring no waste is released into water bodies or soil. Compliance with local regulations for hazardous waste disposal is crucial to protect public health and the environment.