Adefovir Dipivoxyl Impurity A

Basic Information

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CAS Number

142341-05-7

Molecular Formula

C14H22N5O6P

Molecular Weight

387.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Basic Physical Properties

Density

1.50

Flash Point

315℃

SMILES

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CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)O

InChI

InChI=1S/C14H22N5O6P/c1-14(2,3)13(20)24-8-25-26(21,22)9-23-5-4-19-7-18-10-11(15)16-6-17-12(10)19/h6-7H,4-5,8-9H2,1-3H3,(H,21,22)(H2,15,16,17)

InChIKey

MYHVYLHIHRHSDC-UHFFFAOYSA-N

LogP

1.1313999999999997

Topological Polar Surface Area

151.68 Å²

Hydrogen Bond Donor/Acceptor

3 / 11

Complexity

530

Synonyms & References

English

((((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)(hydroxy)phosphoryl)oxy)methyl pivalate
Adefovir Monopivoxil
((((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)-(hydroxy)phosphoryl)oxy)methyl pivalate
9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE,MONO(PIVALOYLOXY)METHYL ESTER
Propanoic acid, 2,2-dimethyl-, [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]hydroxyphosphinyl]oxy]methyl ester
2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphinic acid
2,2-Dimethylpropanoic acid [[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]hydroxyphosphinyl]oxy]methyl ester
A807896
BCP20815
((((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)hydroxyphosphinyl)oxy)methyl 2,2-dimethylpropanoate
DTXSID70438750
9-[2-(Phosphonomethoxy)ethyl]adenine,Mono(pivaloyloxy)methyl Ester
(((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)(hydroxy)phosphoryloxy)methyl pivalate
AKOS015896453
J-007641
2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphinic Acid
SCHEMBL12391569
C14H22N5O6P
CHEMBL54393
[2-(6-AMINOPURIN-9-YL)ETHOXY]METHYL([(2,2-DIMETHYLPROPANOYL)OXY]METHOXY)PHOSPHINIC ACID
142341-05-7
{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}({[(2,2-dimethylpropanoyl)oxy]methoxy})phosphinic acid
2,2-dimethylpropanoic acid,((((2-(6-amino-9h-purin-9-yl)ethoxy)methyl)hydroxyphosphinyl)oxy)methyl ester
((((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)(hydroxy)phosphoryl)oxy)methylpivalate
SC1440
{[{[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl}(hydroxy)phosphoryl]oxy}methyl 2,2-dimethylpropanoate
Mono POM PMEA
((((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)(hydroxy)phosphoryl) oxy)methyl pivalate

MDL Number

MFCD00869902

Customs Code

2933990090

FAQ

What are the physical and chemical properties of Adefovir Dipivoxyl Impurity A (CAS: 142341-05-7)?

Adefovir dipivoxyl impurity A is a solid with a crystalline form. Its molecular weight is approximately 452.51 g/mol. It has a low solubility in water and organic solvents. Chemically, it is not highly reactive but may undergo hydrolysis under basic conditions. Proper storage under dry and cool conditions is recommended.

How is Adefovir Dipivoxyl Impurity A (CAS: 142341-05-7) typically synthesized?

Adefovir dipivoxyl impurity A is typically synthesized through a multi-step organic synthesis route involving acylation and subsequent purification steps. Common catalysts include acid catalysts, and the process yields around 85-90% purity. Detailed reaction conditions and purification techniques are essential for achieving high purity.

What industries use Adefovir Dipivoxyl Impurity A (CAS: 142341-05-7)?

Adefovir dipivoxyl impurity A is primarily used in the pharmaceutical industry, particularly in the production of antiviral drugs. It may also be used in research and development settings for drug formulation and evaluation. Its relevance in the pharmaceutical sector is significant due to its role as a minor impurity in the final product.

What precautions should be taken when handling Adefovir Dipivoxyl Impurity A (CAS: 142341-05-7)?

When handling Adefovir dipivoxyl impurity A, it is important to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. In case of a spill, it is recommended to use appropriate spill kits and consult the safety data sheet (SDS) for specific instructions. Safe storage in a cool, dry place is also recommended to prevent degradation.