Osimertinib | CAS No. 1421373-65-0

Osimertinib

Basic Information

View in Editor

CAS Number

1421373-65-0

Molecular Formula

C28H33N7O2

Molecular Weight

499.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

View in Editor

CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

InChI

InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)

InChIKey

DUYJMQONPNNFPI-UHFFFAOYSA-N

LogP

4.509800000000003

Topological Polar Surface Area

87.55000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

752

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AZD9291
AZD-9291
AZD--9291
n-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-2-propenamide
N(2{[2(diMethylaMino)ethyl](Methyl)aMino}4Methoxy5{[4(1Methyl1Hindol3yl)pyriMidin2yl]aMino}phenyl)prop2enaMide
N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
N-?[2-?[[2-?(dimethylamino)?ethyl]?methylamino]?-?4-?methoxy-?5-?[[4-?(1-?methyl-?1H-?indol-?3-?yl)?
Osimertinib
Osimertinib(AZD9291)
Mereletinib
AZD 9291
Tagrisso
3C06JJ0Z2O
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
AK170511
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
N-(2-{[2-(Dimethylami
N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Osimertinib [USAN]
mereletinib (obsolete INN)
Osimertinib; AZD 9291
SB22952
BDBM50029668
OSIMERTINIB [INN]
osimertinib
BCP08626
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
AZD-9291(Osimertinib)?
N-(2-{2-Dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

MDL Number

MFCD27988062

Customs Code

29339900

FAQ

What is Osimertinib (CAS: 1421373-65-0)?

Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used in cancer treatment. It has the chemical formula C24H28N2O and is known for its high selectivity against EGFR mutations, particularly T790M. Osimertinib is a potent and well-tolerated medication for the treatment of non-small cell lung cancer (NSCLC).

What are the main uses of Osimertinib (CAS: 1421373-65-0)?

Osimertinib is primarily used in oncology to treat non-small cell lung cancer (NSCLC) that has developed resistance to first- or second-generation EGFR inhibitors. It is also used in research for studying EGFR-targeted therapies and in pharmaceutical development for creating similar cancer treatments. Its applications include targeted therapy and personalized medicine for patients with specific genetic mutations.

Is Osimertinib (CAS: 1421373-65-0) safe?

Osimertinib is generally considered safe when used as directed, but it may cause side effects such as diarrhea, rash, and fatigue. Proper handling and adherence to safety guidelines are essential to minimize risks. It is regulated by safety standards to ensure its use in medical settings is appropriate and effective.

How should Osimertinib (CAS: 1421373-65-0) be stored?

Osimertinib should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 30°C (59°F to 86°F) and in airtight containers to maintain stability and potency. Avoid exposure to moisture and high humidity to prevent degradation of the compound.