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(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one | CAS No. 141750-63-2

(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one

Basic Information

Chemical_Structure_Of
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CAS Number

141750-63-2

Molecular Formula

C25H22FNO3

Molecular Weight

428.9 g/mol

AD

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids
Basic Chemical Raw Materials Organic Chemicals Esters
Basic Chemical Raw Materials Organic Chemicals Ethers
Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds
Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates
Fine Chemicals Dyes and Pigments Organic Dyes
Fine Chemicals Surfactants Anionic Surfactants
Fine Chemicals Specialty Chemicals UV Stabilizers
Agricultural Chemicals Pesticides Herbicides
Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

92-95°C

Specific Rotation

D32 +8.84° (c = 0.92 in chloroform)

SMILES

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C1CC1C2=NC3=CC=CC=C3C(=C2C=CC4CC(CC(=O)O4)O)C5=CC=C(C=C5)F

InChI

InChI=1S/C25H22FNO3/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-19-13-18(28)14-23(29)30-19/h1-4,7-12,16,18-19,28H,5-6,13-14H2/b12-11+/t18-,19-/m1/s1

InChIKey

XJVKVAFYQRWVAJ-MCBHFWOFSA-N

LogP

4.030020000000002

Topological Polar Surface Area

102.73 Ų

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

642

Synonyms & References

English

  • Pitavastatin lactone [MI]
  • AC-30587
  • (4R,6S)-6-[(E)-2-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)QUINOLIN-3-YL]ETHENYL]-4-HYDROXYOXAN-2-ONE
  • Q27291134
  • CAS_141750-63-2
  • XJVKVAFYQRWVAJ-MCBHFWOFSA-N
  • SCHEMBL247234
  • BDBM86705
  • UNII-ULK88EV7VQ
  • 141750-63-2
  • (4R,6S)-6-((1E)-2-(2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)ethenyl)tetrahydro-4-hydroxy-2H-pyran-2-one
  • E-6-{2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}-(4R,6S)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
  • HY-125643
  • P-87244
  • (4R,6S)-6-((E)-2-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one
  • Pitavastatin Lactone
  • AKOS030530444
  • ULK88EV7VQ
  • CS-0092571
  • NK-104 (lactone)
  • SCHEMBL247233
  • 2H-Pyran-2-one, 6-((1E)-2-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)ethenyl)tetrahydro-4-hydroxy-, (4R,6S)-
  • Pitavastatin lactone
  • Pitavastatin LactoneDISCONTINUED
  • (4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl]tetrahydro-4-hydroxypyran-2-one
  • (4R,6S)-6-((E)-2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one
  • Pitavastatin Impurity 10

MDL Number

MFCD09841193

FAQ

What regulatory guidelines apply to (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one (CAS: 141750-63-2)?
The compound (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one (CAS: 141750-63-2) is subject to various regulatory guidelines including GHS classification for hazardous chemicals, REACH regulations for the European market, and FDA and EPA requirements for pharmaceutical and environmental safety. Proper documentation and adherence to these guidelines are essential for handling and using this compound.

Are there alternatives to (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one in synthesis?
In the synthesis of (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one (CAS: 141750-63-2), there are several alternatives that can be considered. These include using isomers, analogs, and alternative reagents such as substituted quinolines or different cyclopropyl derivatives. These alternatives may offer improved reactivity, yield, or ease of purification.

What is the market or research trend for (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one (CAS: 141750-63-2)?
The market and research trends for (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one (CAS: 141750-63-2) are currently focused on its potential use in pharmaceuticals, particularly as an intermediate in drug development. Research is exploring its bioavailability, pharmacokinetics, and potential therapeutic applications. Market trends indicate growing interest due to its unique chemical structure and biological activity.

How should waste containing (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one (CAS: 141750-63-2) be handled?
Waste containing (4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one (CAS: 141750-63-2) should be handled according to strict environmental regulations. This includes proper collection, storage, and incineration or professional waste disposal by certified facilities. Precautions should be taken to prevent environmental contamination, and all waste should be managed in compliance with local and international waste disposal guidelines to ensure safety and sustainability.

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Supplier Information

(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one — Hubei Yangxin Pharmaceutical Technology Co., Ltd.

Hubei Yangxin Pharmaceutical Technology Co., Ltd.

CAS Number: 141750-63-2

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Shanghai Yubin Technology Co., Ltd.

CAS Number: 141750-63-2

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(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one — HePeng （ ShangHai ） Biotechnology Co Ltd

HePeng （ ShangHai ） Biotechnology Co Ltd

CAS Number: 141750-63-2

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(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one — Shenzhen Moho BioTechnology Co., Ltd.

Shenzhen Moho BioTechnology Co., Ltd.

CAS Number: 141750-63-2

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Shanghai Kewei Chemical Technology Co., Ltd.

CAS Number: 141750-63-2

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Hubei Hanwei Chemical Co., Ltd.

CAS Number: 141750-63-2

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(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one — ShangHaiYiJiShengWuKeJiYouXianGongSiXiaoShouBu

ShangHaiYiJiShengWuKeJiYouXianGongSiXiaoShouBu

CAS Number: 141750-63-2

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(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one — ShenZhenZhenJiangShengWuJiShu Co Ltd

ShenZhenZhenJiangShengWuJiShu Co Ltd

CAS Number: 141750-63-2

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Shenzhen Hengfeng Wanda Drug Research Co., Ltd.

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HuBeiGuoYunFuRui Technology Co Ltd

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ShanDongZhongKeTaiDouHuaXue Co Ltd

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ShangHaiGuDuo Biotechnology Co Ltd

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Shanghai Aladdin Bio-Technologies Co., Ltd.

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DaDaoShengWuKeJi （ ShaoXing ） Co Ltd

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(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one — ShenZhenAiTaHuaXue Co Ltd

ShenZhenAiTaHuaXue Co Ltd

CAS Number: 141750-63-2

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