5-Ethyl-1,3,4-thiadiazol-2-amine

Basic Information

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CAS Number

14068-53-2

Molecular Formula

C4H7N3S

Molecular Weight

129.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

200-203 °C

Boiling Point

250

Flash Point

115.4°C

Refractive Index

1.5800 (estimate)

SMILES

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CCC1=NN=C(S1)N

InChI

InChI=1S/C4H7N3S/c1-2-3-6-7-4(5)8-3/h2H2,1H3,(H2,5,7)

InChIKey

QXTRPGAMVIONMK-UHFFFAOYSA-N

LogP

0.6827000000000001

Topological Polar Surface Area

51.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

77.7

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

EINECS 237-921-4
NSC 75711
AKOS000100064
bmse000176
FT-0611168
BS-3768
NSC75711
1,3,4-Thiadiazol-2-amine, 5-ethyl-
SCHEMBL94109
N859FE3PD7
14068-53-2
1,3,4-THIADIAZOLE, 2-AMINO-5-ETHYL-
5-Ethyl-[1,3,4]thiadiazol-2-ylamine
2-Amino-5-ethyl-1,3,4-thiadiazole, 97%
CHEBI:86540
1,4-Thiadiazol-2-amine, 5-ethyl-
4-27-00-08073 (Beilstein Handbook Reference)
2-Amino-5-ethyl-1,3,4-thiadiazole
W-108197
3vp4
MZW
Z57052870
5-Ethyl-1,3,4-thiadiazol-2-amine
BRN 0113614
AM90247
Q27159228
BB 0217151
NS00024561
BP9
MFCD00003111
5-Ethyl-1,3,4-thiadiazol-2-amine #

MDL Number

MFCD00003111

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 5-Ethyl-1,3,4-thiadiazol-2-amine (CAS: 14068-53-2)?

5-Ethyl-1,3,4-thiadiazol-2-amine (CAS: 14068-53-2) is a crystalline compound with a molecular weight of approximately 134.17 g/mol. It has a high solubility in polar solvents such as methanol and ethanol but is less soluble in water. This amine is known for its reactivity in nucleophilic substitution reactions. It is stable under normal conditions but should be handled with care in the presence of strong oxidizers or reductants.

How is 5-Ethyl-1,3,4-thiadiazol-2-amine (CAS: 14068-53-2) typically synthesized?

5-Ethyl-1,3,4-thiadiazol-2-amine can be synthesized via a multi-step process. A common method involves the reaction of 5-bromo-1,3,4-thiadiazole with ethylamine. The reaction is typically carried out under basic conditions with a catalyst such as potassium carbonate. The product is then purified by column chromatography or recrystallization, yielding a high-purity crystalline compound with good selectivity and yield.

What industries use 5-Ethyl-1,3,4-thiadiazol-2-amine (CAS: 14068-53-2)?

5-Ethyl-1,3,4-thiadiazol-2-amine (CAS: 14068-53-2) finds applications in various industries. It is used in pharmaceuticals as an intermediate in the synthesis of certain drugs. It also has applications in polymer chemistry for the modification of polymers, and in the production of sensors and semiconductors due to its unique electronic properties.

What precautions should be taken when handling 5-Ethyl-1,3,4-thiadiazol-2-amine (CAS: 14068-53-2)?

When handling 5-Ethyl-1,3,4-thiadiazol-2-amine (CAS: 14068-53-2), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be used in a well-ventilated area or in a fume hood to minimize inhalation risks. In the event of a spill, it should be cleaned up using appropriate spill response procedures. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.