Azilsartan Impurity 19

Basic Information

View in Editor

CAS Number

1403474-70-3

Molecular Formula

C27H24N4O5

Molecular Weight

484.51 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Solubility

Insuluble (3.2E-5 g/L) (25 ºC),

SMILES

View in Editor

CCOc1nc2cccc(c2n1Cc3ccc(cc3)c4ccccc4c5[nH]oc(=O)n5)C(=O)OCC

InChI

InChI=1S/C27H24N4O5/c1-3-34-25(32)21-10-7-11-22-23(21)31(26(28-22)35-4-2)16-17-12-14-18(15-13-17)19-8-5-6-9-20(19)24-29-27(33)36-30-24/h5-15H,3-4,16H2,1-2H3,(H,29,30,33)

InChIKey

OWLFNOWZZXCCNU-UHFFFAOYSA-N

LogP

4.670300000000004

Topological Polar Surface Area

112.24000000000002 Å²

Hydrogen Bond Donor/Acceptor

1 / 9

Complexity

814

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester
ethyl ester of azilsartan
ethyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
Ethyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
ETHYL 2-ETHOXY-1-((2-(5-OXO-2,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)-[1,1-BIPHENYL]-4-YL)METHYL)-1H-BENZO[D]IMIDAZOLE-7-CARBOXYLATE
AK341747
ethyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
ethyl 2-ethoxy-1-({4-[2-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3
Ethyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxyl
Ethyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
Ethyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

MDL Number

MFCD28404679

FAQ

What regulatory guidelines apply to Azilsartan Impurity 19 (CAS: 1403474-70-3)?

Azilsartan Impurity 19 (CAS: 1403474-70-3) should comply with the REACH regulations in the European Union, which require manufacturers and importers to register substances and evaluate their safety. In the United States, it must also adhere to FDA guidelines for the import and sale of chemical substances, as well as EPA regulations for handling and disposal. Additionally, it should follow GHS classification for hazardous substances and ensure proper labeling and safety data sheets are provided.

Are there alternatives to Azilsartan Impurity 19 (CAS: 1403474-70-3) in synthesis?

In the synthesis of azilsartan, alternative reagents such as 1H-indazole or 2-amino-4-(1H-indazol-5-yl)benzene can be used as precursors. Isomers and analogs of Azilsartan Impurity 19 may also serve as viable alternatives, but thorough testing is necessary to ensure they meet the required specifications and do not introduce unwanted impurities.

What is the market or research trend for Azilsartan Impurity 19 (CAS: 1403474-70-3)?

The market for Azilsartan Impurity 19 is driven by ongoing research and development in the pharmaceutical industry, particularly in the area of hypertension treatment. Recent trends indicate a growing focus on quality control and impurity analysis in drug manufacturing, which has increased the demand for accurate and reliable impurity standards. Emerging research is also exploring new methods for impurity detection and removal, which could further influence market dynamics.

How should waste containing Azilsartan Impurity 19 (CAS: 1403474-70-3) be handled?

Waste containing Azilsartan Impurity 19 should be collected in sealed, labeled containers and stored in a secure, well-ventilated area. It should be disposed of through professional waste disposal services that are compliant with local regulations. Incineration is a common method, but the temperature must be carefully controlled to prevent the release of harmful substances. Environmental protection measures, such as neutralizing any potential acidic or basic components, should be followed to ensure minimal environmental impact.